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http://hdl.handle.net/2445/133598
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DC Field | Value | Language |
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dc.contributor.author | Molinar Toribio, Eunice María | - |
dc.contributor.author | Fuguet i Jordà, Elisabet | - |
dc.contributor.author | Ramos Romero, Sara | - |
dc.contributor.author | Taltavull, Núria | - |
dc.contributor.author | Méndez, Lucía | - |
dc.contributor.author | Nogués, M. Rosa | - |
dc.contributor.author | Medina, Isabel | - |
dc.contributor.author | Torres Simón, Josep Lluís | - |
dc.contributor.author | Pérez-Jiménez, Jara | - |
dc.date.accessioned | 2019-05-21T12:44:58Z | - |
dc.date.available | 2019-05-21T12:44:58Z | - |
dc.date.issued | 2018-02 | - |
dc.identifier.issn | 1436-6207 | - |
dc.identifier.uri | http://hdl.handle.net/2445/133598 | - |
dc.description.abstract | Purpose Polyphenol metabolites are key mediators of the biological activities of polyphenols. This study aimed to evaluate the long-term effects of a high-fat high-sucrose (HFHS) diet on the metabolism of proanthocyanidins from grape seed extract (GSE). Methods Adult female Wistar-Kyoto rats were fed a standard (STD) or HFHS diet supplemented or not with GSE for 16 weeks. PA metabolites were determined by targeted HPLC-MS/MS analysis. Results A lower concentration of total microbial-derived PA metabolites was present in urine and the aqueous fraction of faeces in the HFHS + GSE group than in the STD + GSE group. In contrast, a tendency towards the formation of conjugated (epi)catechin metabolites in the HFHS + GSE group was observed. Conclusions These results show that a HFHS diet significantly modifies PA metabolism, probably via: (1) a shift in microbial communities not counteracted by the polyphenols themselves; and (2) an up-regulation of hepatic enzymes. | - |
dc.format.extent | 11 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer Verlag | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1007/s00394-016-1323-9 | - |
dc.relation.ispartof | European Journal of Nutrition, 2018, vol. 57, p. 339-349 | - |
dc.relation.uri | https://doi.org/10.1007/s00394-016-1323-9 | - |
dc.rights | (c) Springer Verlag, 2018 | - |
dc.source | Articles publicats en revistes (Enginyeria Química i Química Analítica) | - |
dc.subject.classification | Polifenols | - |
dc.subject.classification | Metabòlits | - |
dc.subject.classification | Dieta | - |
dc.subject.classification | Biodisponibilitat | - |
dc.subject.other | Polyphenols | - |
dc.subject.other | Metabolites | - |
dc.subject.other | Diet | - |
dc.subject.other | Bioavailability | - |
dc.title | A high-fat high-sucrose diet affects the long-term metabolic fate of grape proanthocyanidins in rats | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 667125 | - |
dc.date.updated | 2019-05-21T12:44:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Enginyeria Química i Química Analítica) |
Files in This Item:
File | Description | Size | Format | |
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667125.pdf | 414.15 kB | Adobe PDF | View/Open |
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