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Title: Polyamidoamine Nanoparticles for the Oral Administration of Antimalarial Drugs
Author: Martí Coma Cros, Elisabet
Biosca, Arnau
Marques, Joana
Carol, Laura
Urbán, Patricia
Berenguer, Diana
Riera Lizandra, Ma. Cristina
Delves, Michael
Sinden, Robert E.
Valle Delgado, Juan José
Spanos, Lefteris
Siden-Kiamos, Inga
Pérez, Paula
Paaijmans, Krijn P.
Rottmann, Matthias
Manfredi, Amedea
Ferruti, Paolo
Ranucci, Elisabetta
Fernàndez Busquets, Xavier
Keywords: Malària
Issue Date: 10-Nov-2018
Publisher: MDPI
Abstract: Current strategies for the mass administration of antimalarial drugs demand oral formulations to target the asexual Plasmodium stages in the peripheral bloodstream, whereas recommendations for future interventions stress the importance of also targeting the transmission stages of the parasite as it passes between humans and mosquitoes. Orally administered polyamidoamine (PAA) nanoparticles conjugated to chloroquine reached the blood circulation and cured Plasmodium yoelii-infected mice, slightly improving the activity of the free drug and inducing in the animals immunity against malaria. Liquid chromatography with tandem mass spectrometry analysis of affinity chromatography-purified PAA ligands suggested a high adhesiveness of PAAs to Plasmodium falciparum proteins, which might be the mechanism responsible for the preferential binding of PAAs to Plasmodium-infected erythrocytes vs. non-infected red blood cells. The weak antimalarial activity of some PAAs was found to operate through inhibition of parasite invasion, whereas the observed polymer intake by macrophages indicated a potential of PAAs for the treatment of certain coinfections such as Plasmodium and Leishmania. When fluorescein-labeled PAAs were fed to females of the malaria mosquito vectors Anopheles atroparvus and Anopheles gambiae, persistent fluorescence was observed in the midgut and in other insect's tissues. These results present PAAs as a versatile platform for the encapsulation of orally administered antimalarial drugs and for direct administration of antimalarials to mosquitoes, targeting mosquito stages of Plasmodium
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It is part of: Pharmaceutics, 2018, vol. 10, num. 4, p. 225
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ISSN: 1999-4923
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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