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http://hdl.handle.net/2445/134299
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DC Field | Value | Language |
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dc.contributor.author | Ropero, Ana B. | - |
dc.contributor.author | Soriano, Sergi | - |
dc.contributor.author | Tudurí, Eva | - |
dc.contributor.author | Marroquí, Laura | - |
dc.contributor.author | Téllez i Besolí, Noèlia | - |
dc.contributor.author | Gassner, Birgit | - |
dc.contributor.author | Juan-Picó, Pablo | - |
dc.contributor.author | Montanya Mias, Eduard | - |
dc.contributor.author | Quesada, Ivan | - |
dc.contributor.author | Kuhn, Michaela | - |
dc.contributor.author | Nadal, Angel | - |
dc.date.accessioned | 2019-05-31T17:33:47Z | - |
dc.date.available | 2019-05-31T17:33:47Z | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 0013-7227 | - |
dc.identifier.uri | http://hdl.handle.net/2445/134299 | - |
dc.description.abstract | Atrial natriuretic peptide (ANP) and its guanylyl cyclase-A (GC-A) receptor are being involved in metabolism, although their role in the endocrine pancreas is still greatly unknown. The aim of this work is to study a possible role for the ANP/GC-A system in modulating pancreatic beta-cell function. The results presented here show a direct effect of the GC-A receptor in regulating glucose-stimulated insulin secretion (GSIS) and beta-cell mass. GC-A activation by its natural ligand, ANP, rapidly blocked ATP-dependent potassium (K(ATP)) channel activity, increased glucose-elicited Ca(2+) signals, and enhanced GSIS in islets of Langerhans. The effect in GSIS was inhibited in islets from GC-A knockout (KO) mice. Pancreatic islets from GC-A KO mice responded to increasing glucose concentrations with enhanced insulin secretion compared with wild type (WT). Remarkably, islets from GC-A KO mice were smaller, presented lower beta-cell mass and decreased insulin content. However, glucose-induced Ca(2+) response was more vigorous in GC-A KO islets, and basal K(ATP) channel activity in GC-A KO beta-cells was greatly diminished compared with WT. When protein levels of the two K(ATP) channel constitutive subunits sulfonylurea receptor 1 and Inward rectifier potassium channel 6.2 were measured, both were diminished in GC-A KO islets. These alterations on beta-cell function were not associated with disruption of glucose tolerance or insulin sensitivity in vivo. Glucose and insulin tolerance tests were similar in WT and GC-A KO mice. Our data suggest that the ANP/GC-A system may have a modulating effect on beta-cell function. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Association for the Study of Internal Secretions | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1210/en.2010-0119 | - |
dc.relation.ispartof | Endocrinology, 2010, vol. 151, num. 8, p. 3665-3674 | - |
dc.relation.uri | https://doi.org/10.1210/en.2010-0119 | - |
dc.rights | (c) Association for the Study of Internal Secretions, 2010 | - |
dc.source | Articles publicats en revistes (Ciències Clíniques) | - |
dc.subject.classification | Fisiologia | - |
dc.subject.classification | Secreció | - |
dc.subject.classification | Insulina | - |
dc.subject.classification | Pèptids | - |
dc.subject.other | Physiology | - |
dc.subject.other | Secretion | - |
dc.subject.other | Insulin | - |
dc.subject.other | Peptides | - |
dc.title | The atrial natriuretic peptide and guanylyl cyclase-A system modulates pancreatic beta-cell function | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 630888 | - |
dc.date.updated | 2019-05-31T17:33:47Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 20555029 | - |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) |
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File | Description | Size | Format | |
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630888.pdf | 408.05 kB | Adobe PDF | View/Open |
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