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Title: Force-Dependent Fragility in RNA Hairpins
Author: Mañosas Castejón, María
Collin, D.
Ritort Farran, Fèlix
Keywords: RNA
Issue Date: 31-May-2006
Publisher: American Physical Society
Abstract: We apply Kramers theory to investigate the dissociation of multiple bonds under mechanical force and interpret experimental results for the unfolding and refolding force distributions of an RNA hairpin pulled at different loading rates using laser tweezers. We identify two different kinetic regimes depending on the range of forces explored during the unfolding and refolding process. The present approach extends the range of validity of the two-states approximation by providing a theoretical framework to reconstruct free-energy landscapes and identify force-induced structural changes in molecular transition states using single molecule pulling experiments. The method should be applicable to RNA hairpins with multiple kinetic barriers.
Note: Reproducció del document publicat a:
It is part of: Physical Review Letters, 2006, vol. 96, num. 21, p. 218301
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ISSN: 0031-9007
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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