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Title: Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project
Author: Dierssen Sotos, Trinidad
Palazuelos Calderón, Camilo
Jiménez Moleón, José Juan
Aragonés, Nuria
Altzibar, Jone M.
Castaño Vinyals, Gemma
Martín Sanchez, Vicente
Gómez Acebo, Inés
Guevara, Marcela
Tardón, Adonina
Pérez Gómez, Beatriz
Amiano, Pilar
Moreno Aguado, Víctor
Molina, Antonio J.
Alonso Molero, Jéssica
Moreno Iribas, Conchi
Kogevinas, Manolis
Pollán, Marina
Llorca Díaz, Javier
Keywords: Càncer de mama
Reproducció humana
Breast cancer
Human reproduction
Issue Date: 12-Mar-2018
Publisher: BioMed Central
Abstract: BACKGROUND: Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. METHODS: One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. RESULTS: Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. CONCLUSIONS: The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.
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It is part of: BMC Cancer, 2018, vol. 18, p. 280
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ISSN: 1471-2407
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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