Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/137238
Title: Primary respiratory disease in patients with systemic lupus erythematosus: data from the Spanish rheumatology society lupus registry (RELESSER) cohort
Author: Narváez García, Francisco Javier
Borrell, Helena
Sánchez Alonso, Fernando
Rúa Figueroa, Iñigo
López Longo, Francisco J.
Galindo Izquierdo, María
Calvo Alén, Jaime
Fernández Nebro, Antonio
Olivé Marqués, Alejandro
Andreu, José Luis
Martínez Taboada, Víctor
Nolla Solé, Joan Miquel
Pego Reigosa, José María
RELESSER Study Group
Keywords: Lupus eritematós
Malalties de la pleura
Malalties dels pulmons
Pronòstic mèdic
Lupus erythematosus
Pleural disease
Pulmonary diseases
Prognosis
Issue Date: 19-Dec-2018
Publisher: BioMed Central
Abstract: Background The purpose of this study was to assess the prevalence, associated factors, and impact on mortality of primary respiratory disease in a large systemic lupus erythematosus (SLE) retrospective cohort. Methods All adult patients in the RELESSER-TRANS (Registry of Systemic Lupus Erythematosus Patients of the Spanish Society of Rheumatology [SER], cross-sectional phase) registry were retrospectively investigated for the presence of primary pleuropulmonary manifestations. Results In total 3215 patients were included. At least one pleuropulmonary manifestation was present in 31% of patients. The most common manifestation was pleural disease (21%), followed by lupus pneumonitis (3.6%), pulmonary thromboembolism (2.9%), primary pulmonary hypertension (2.4%), diffuse interstitial lung disease (2%), alveolar hemorrhage (0.8%), and shrinking lung syndrome (0.8%). In the multivariable analysis, the variables associated with the development of pleuropulmonary manifestation were older age at disease onset (odds ratio (OR) 1.03, 95% confidence interval (CI) 1.02-1.04), higher SLEDAI (Systemic Lupus Erythematosus Disease Activity Index) scores (OR 1.03, 95% CI 1.00-1.07), the presence of Raynaud's phenomenon (OR 1.41, 95% CI 1.09-1.84), secondary antiphospholipid syndrome (OR 2.20, 95% CI 1.63-2.97), and the previous or concomitant occurrence of severe lupus nephritis, (OR 1.48, 95% CI 1.12-1.95) neuropsychiatric manifestations (OR 1.49, 95% CI 1.11-2.02), non-ischemic cardiac disease (OR 2.91, 95% CI 1.90-4.15), vasculitis (OR 1.81, 95% CI 1.25-2.62), hematological manifestations (OR 1.31, 95% CI 1.00-1.71), and gastrointestinal manifestations, excluding hepatitis (OR 2.05, 95% CI 1.14-3.66). Anti-RNP positivity had a clear tendency to significance (OR 1.32, 95% CI 1.00-1.75; P = 0.054). The development of pleuropulmonary manifestations independently contributes to a diminished survival (hazard ratio of 3.13). However, not all complications will influence the prognosis in the same way. Whereas the occurrence of pleural disease or pulmonary thromboembolism has a minimal impact on the survival of these patients, the remaining manifestations have a major impact on mortality. Conclusion Except for pleural disease, the remaining respiratory manifestations are very uncommon in SLE (<4%). Pleuropulmonary manifestations independently contributed to a decreased survival in these patients.
Note: Reproducció del document publicat a: https://doi.org/10.1186/s13075-018-1776-8
It is part of: Arthritis Research & Therapy, 2018, vol. 20, num. 1, p. 280
URI: http://hdl.handle.net/2445/137238
Related resource: https://doi.org/10.1186/s13075-018-1776-8
ISSN: 1478-6362
Appears in Collections:Articles publicats en revistes (Ciències Clíniques)

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