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http://hdl.handle.net/2445/138217
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DC Field | Value | Language |
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dc.contributor.advisor | Riera i Escalé, Antoni | - |
dc.contributor.advisor | Cabré Montesinos, Albert | - |
dc.contributor.author | Rafael Miguel, Sergi | - |
dc.date.accessioned | 2019-07-25T07:39:58Z | - |
dc.date.available | 2020-06-20T05:10:27Z | - |
dc.date.issued | 2019-06 | - |
dc.identifier.uri | http://hdl.handle.net/2445/138217 | - |
dc.description | Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2019, Tutors: Antoni Riera Escalé, Albert Cabré Montesinos | ca |
dc.description.abstract | The synthesis of enantiomerically pure compounds is one of the main challenges in organic synthesis. Particularly, γ-chiral alcohols are a valuable chemical motif and a useful building block, especially in the pharmaceutical industry. Even though there are several synthetic methodologies already studied, they offer poor atom economy reactions and there is a need of separation steps, consequently lowering the final yield. For this reason, a new approach would be highly desired. Most promising approaches undergo isomerization reactions that are highly atom economy efficient and generate low to no residues. Still there is not a selective procedure to the isomerization of oxetanes. In this work, a new general and greener synthetic pathway has been developed. This new approach is based on the Lewis-acid-promoted selective isomerization of oxetane rings. Afterwards, the correspondent olefin is subjected to an asymmetric hydrogenation using iridiumbased catalysts. A standard substrate has been tested in order to optimize the methodology. Finally, a broad scope of substrates has been studied to generalize the process | ca |
dc.format.extent | 44 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | ca |
dc.rights | cc-by-nc-nd (c) Rafael, 201 | - |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/es/ | * |
dc.source | Treballs Finals de Grau (TFG) - Química | - |
dc.subject.classification | Alcohols | cat |
dc.subject.classification | Àcids de Lewis | cat |
dc.subject.classification | Isomerització | cat |
dc.subject.classification | Hidrogenació | cat |
dc.subject.classification | Treballs de fi de grau | - |
dc.subject.other | Alcohols | eng |
dc.subject.other | Lewis acids | eng |
dc.subject.other | Isomerization | eng |
dc.subject.other | Hydrogenation | - |
dc.subject.other | Bachelor's theses | - |
dc.title | Lewis-acid-promoted selective isomerization of oxetanes. New synthetic approach towards γ-chiral alcohols | ca |
dc.title.alternative | Isomerització selectiva d’oxetans induïda per àcid de Lewis. Nou enfoc sintètic cap a alcohols γ-quirals | ca |
dc.type | info:eu-repo/semantics/bachelorThesis | ca |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Treballs Finals de Grau (TFG) - Química |
Files in This Item:
File | Description | Size | Format | |
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TFG_QU Rafael Miguel, Sergi.pdf | 1.15 MB | Adobe PDF | View/Open |
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