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Title: Anti-inflammatory activity in selected Antarctic benthic organisms
Author: Moles Sánchez, Juan
Torrent, Anna
Alcaraz, María José (Alcaraz Tormo)
Ruhí, Ramon
Ávila Escartín, Conxita
Keywords: Organismes aquàtics
Antàrtic, Oceà
Aquatic organisms
Antarctic Ocean
Issue Date: 22-Jul-2014
Publisher: Frontiers Media
Abstract: Antarctic benthos was prospected in search for anti-inflammatory activity in polar benthic invertebrates, in two different geographical areas: deep-bottoms of the Eastern Weddell Sea and shallow-waters of the South Shetland Islands. A total of 36 benthic algae and invertebrate species were selected to perform solubility tests in order to obtain extracts that were soluble at an innocuous ethanol concentration (0.2%) for cell culture, and further test them for anti-inflammatory activity. From these, ethanol extracts of ten species from five different phyla resulted suitable to be studied in cell macrophage cultures (RAW 264.7). Cytotoxicity (MTT method) and production of inflammatory mediators (prostaglandin E2, leukotriene B4, interleukin-1β) were determined at three extract concentrations (50, 125, 250 μg/mL). Bioassays resulted in four different species showing anti-inflammatory activity corresponding to three sponges: Mycale (Oxymycale) acerata, Isodictya erinacea, and I. toxophila; and one hemichordate: Cephalodiscus sp. These results show that Antarctic sessile invertebrates may have great value as a source of lead compounds with potential pharmaceutical applications.
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It is part of: Frontiers in Marine Science, 2014, vol. 1, p. 24
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ISSN: 2296-7745
Appears in Collections:Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)

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