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DC Field | Value | Language |
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dc.contributor.author | Franco Fernández, Rafael | - |
dc.contributor.author | Martínez-Pinilla, Eva | - |
dc.contributor.author | Lanciego, José Luis | - |
dc.contributor.author | Navarro Brugal, Gemma | - |
dc.date.accessioned | 2019-07-30T10:23:56Z | - |
dc.date.available | 2019-07-30T10:23:56Z | - |
dc.date.issued | 2016-03-31 | - |
dc.identifier.issn | 1663-9812 | - |
dc.identifier.uri | http://hdl.handle.net/2445/138585 | - |
dc.description.abstract | Cell membrane receptors rarely work on isolation, often they form oligomeric complexes with other receptor molecules and they may directly interact with different proteins of the signal transduction machinery. For a variety of reasons, rhodopsin-like class A G-protein coupled receptors (GPCRs) seem an exception to the general rule of receptor receptor direct interaction. In fact, controversy surrounds their potential to form homo-heterodimers/oligomers with other class A GPCRs; in a sense, the field is going backward instead of forward. This review focuses on the convergent, complementary and telling evidence showing that homo- and heteromers of class A GPCRs exist in transfected cells and, more importantly, in natural sources. It is time to decide between questioning the occurrence of heteromers or, alternatively, facing the vast scientific and technical challenges that class A receptor-dimer/oligomer existence pose to Pharmacology and to Drug Discovery. | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3389/fphar.2016.00076 | - |
dc.relation.ispartof | Frontiers in Pharmacology, 2016, vol. 7, p. 76 | - |
dc.relation.uri | https://doi.org/10.3389/fphar.2016.00076 | - |
dc.rights | cc-by (c) Franco Fernández, Rafael et al., 2016 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) | - |
dc.subject.classification | Proteïnes G | - |
dc.subject.classification | Farmacologia | - |
dc.subject.other | G Proteins | - |
dc.subject.other | Pharmacology | - |
dc.title | Basic pharmacological and structural evidence for class A G-protein-coupled receptor heteromerization | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 668471 | - |
dc.date.updated | 2019-07-30T10:23:56Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 27065866 | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Bioquímica i Fisiologia) |
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File | Description | Size | Format | |
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668471.pdf | 426.84 kB | Adobe PDF | View/Open |
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