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Title: Risk and protective factors for anxiety and obsessive-compulsive disorders: an umbrella review of systematic reviews and meta-analyses
Author: Fullana, Miquel A.
Tortella Feliu, Miquel
Fernández de la Cruz, Lorena
Chamorro, Jacobo
Pérez-Vigil, Ana
Ioannidis, John P. A.
Solanes, Aleix
Guardiola, Maria
Almodóvar, Carmen
Miranda-Olivos, Romina
Ramella-Cravaro, Valentina
Vilar, Ana
Reichenberg, Abraham
Mataix-Cols, David
Vieta i Pascual, Eduard, 1963-
Fusar-Poli, Paolo
Fatjó-Vilas Mestre, Mar
Radua, Joaquim
Keywords: Depressió psíquica
Mental depression
Issue Date: 7-Jun-2019
Publisher: Cambridge University Press
Abstract: A multitude of risk/protective factors for anxiety and obsessive-compulsive disorders have been proposed. We conducted an umbrella review to summarize the evidence of the associations between risk/protective factors and each of the following disorders: specific phobia, social anxiety disorder, generalized anxiety disorder, panic disorder, and obsessive-compulsive disorder, and to assess the strength of this evidence whilst controlling for several biases.Publication databases were searched for systematic reviews and meta-analyses examining associations between potential risk/protective factors and each of the disorders investigated. The evidence of the association between each factor and disorder was graded into convincing, highly suggestive, suggestive, weak, or non-significant according to a standardized classification based on: number of cases (>1000), random-effects p-values, 95% prediction intervals, confidence interval of the largest study, heterogeneity between studies, study effects, and excess of significance.Nineteen systematic reviews and meta-analyses were included, corresponding to 216 individual studies covering 427 potential risk/protective factors. Only one factor association (early physical trauma as a risk factor for social anxiety disorder, OR 2.59, 95% CI 2.17-3.1) met all the criteria for convincing evidence. When excluding the requirement for more than 1000 cases, five factor associations met the other criteria for convincing evidence and 22 met the remaining criteria for highly suggestive evidence.Although the amount and quality of the evidence for most risk/protective factors for anxiety and obsessive-compulsive disorders is limited, a number of factors significantly increase the risk for these disorders, may have potential prognostic ability and inform prevention.
Note: Versió postprint del document publicat a:
It is part of: Psychological Medicine, 2020, vol. 50, num. 5, p. 1300-1315
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ISSN: 0033-2917
Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Biologia Evolutiva, Ecologia i Ciències Ambientals)
Articles publicats en revistes (Institut de Biomedicina (IBUB))

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