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Title: Active fingering instability in tissue spreading
Author: Alert Zenón, Ricard
Blanch Mercader, Carles
Casademunt i Viader, Jaume
Keywords: Cèl·lules epitelials
Teixits (Histologia)
Pel·lícules fines
Epithelial cells
Thin films
Issue Date: 1-Mar-2019
Publisher: American Physical Society
Abstract: During the spreading of epithelial tissues, the advancing tissue front often develops fingerlike protrusions. Their resemblance to traditional viscous fingering patterns in driven fluids suggests that epithelial fingers could arise from an interfacial instability. However, the existence and physical mechanism of such a putative instability remain unclear. Here, based on an active polar fluid model for epithelial spreading, we analytically predict a generic instability of the tissue front. On the one hand, active cellular traction forces impose a velocity gradient that leads to an accelerated front, which is, thus, unstable to long-wavelength perturbations. On the other hand, contractile intercellular stresses typically dominate over surface tension in stabilizing short-wavelength perturbations. Finally, the finite range of hydrodynamic interactions in the tissue selects a wavelength for the fingering pattern, which is, thus, given by the smallest between the tissue size and the hydrodynamic screening length. Overall, we show that spreading epithelia experience an active fingering instability based on a simple kinematic mechanism. Moreover, our results underscore the crucial role of long-range hydrodynamic interactions in the dynamics of tissue morphology.
Note: Reproducció del document publicat a:
It is part of: Physical Review Letters, 2019, vol. 122, num. 8, p. 088194
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ISSN: 0031-9007
Appears in Collections:Articles publicats en revistes (Física de la Matèria Condensada)

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