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Title: Enantioselective Synthesis of β-Methyl Amines via Iridium-Catalyzed Asymmetric Hydrogenation of N-Sulfonyl Allyl Amines.
Author: Cabré Montesinos, Albert
Verdaguer i Espaulella, Xavier
Riera i Escalé, Antoni
Keywords: Iridi
Catàlisi asimètrica
Síntesi de fàrmacs
Enantioselective catalysis
Drug synthesis
Issue Date: 5-Aug-2019
Publisher: Wiley-VCH
Abstract: The iridium-catalyzed asym. hydrogenation of several N-sulfonyl allyl amines was reported. All substrates could be easily obtained by the Ir-catalyzed isomerization of N-tosylaziridines reported previously. The com. available threonine-derived phosphinite (UbaPHOX) iridium complex had been found to be the best catalyst for this catalytic application, affording β-Me amines I [R1 = H, 4-Cl, 4-Br, etc.;R2 = Me, i-Pr, 4-MeC6H4; R3 = H, Me] with good to excellent ee values (up to 94%). The synthetic potential of this novel methodol. was demonstrated by the formal synthesis of Lorcaserin and LY-404187.
Note: Versió postprint del document publicat a:
It is part of: Advanced Synthesis & Catalysis, 2019, vol. 361, num. 18, p. 4196-4200
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ISSN: 1615-4150
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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