Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/147922
Title: Intrinsically regulated learning is modulated by synaptic dopamine signaling
Author: Ripollés, Pablo
Ferreri, L.
Mas-Herrero, Ernest
Alicart, H.
Gomez Andres, Alba
Marco Pallarés, Josep
Antonijoan Arbós, Rosa Ma. (Rosa María)
Noesselt, Toemme
Valle, Marta
Riba, J.
Rodríguez Fornells, Antoni
Keywords: Aprenentatge
Fisiologia
Neurotransmissió
Transducció de senyal cel·lular
Learning
Physiology
Neural transmission
Cellular signal transduction
Issue Date: 30-Sep-2018
Publisher: eLife Sciences
Abstract: We recently provided evidence that an intrinsic reward-related signal-triggered by successful learning in absence of any external feedback-modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success.
Note: Reproducció del document publicat a: https://doi.org/10.7554/eLife.38113
It is part of: eLife, 2018, vol. 7, p. e38113
URI: http://hdl.handle.net/2445/147922
Related resource: https://doi.org/10.7554/eLife.38113
ISSN: 2050-084X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació)

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