Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/147922
Title: | Intrinsically regulated learning is modulated by synaptic dopamine signaling |
Author: | Ripollés, Pablo Ferreri, Laura Mas-Herrero, Ernest Alicart, Helena Gómez Andrés, Alba Marco Pallarés, Josep Antonijoan Arbós, Rosa Ma. (Rosa María) Noesselt, Toemme Valle, Marta Riba, Jordi Rodríguez Fornells, Antoni |
Keywords: | Aprenentatge Fisiologia Neurotransmissió Transducció de senyal cel·lular Learning Physiology Neural transmission Cellular signal transduction |
Issue Date: | 30-Sep-2018 |
Publisher: | eLife Sciences |
Abstract: | We recently provided evidence that an intrinsic reward-related signal-triggered by successful learning in absence of any external feedback-modulated the entrance of new information into long-term memory via the activation of the dopaminergic midbrain, hippocampus, and ventral striatum (the SN/VTA-Hippocampal loop; Ripollés et al., 2016). Here, we used a double-blind, within-subject randomized pharmacological intervention to test whether this learning process is indeed dopamine-dependent. A group of healthy individuals completed three behavioral sessions of a language-learning task after the intake of different pharmacological treatments: a dopaminergic precursor, a dopamine receptor antagonist or a placebo. Results show that the pharmacological intervention modulated behavioral measures of both learning and pleasantness, inducing memory benefits after 24 hr only for those participants with a high sensitivity to reward. These results provide causal evidence for a dopamine-dependent mechanism instrumental in intrinsically regulated learning and further suggest that subject-specific reward sensitivity drastically alters learning success. |
Note: | Reproducció del document publicat a: https://doi.org/10.7554/eLife.38113 |
It is part of: | eLife, 2018, vol. 7, p. e38113 |
URI: | http://hdl.handle.net/2445/147922 |
Related resource: | https://doi.org/10.7554/eLife.38113 |
ISSN: | 2050-084X |
Appears in Collections: | Articles publicats en revistes (Cognició, Desenvolupament i Psicologia de l'Educació) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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