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Title: Stereoselective decarboxylative alkylation of titanium(IV) enolates with diacyl peroxides
Author: Gómez Palomino, Alejandro
Pérez-Palau, Marina
Romea, Pedro
Urpí Tubella, Fèlix
Del Olmo, Marc
Hesse, Timo
Fleckenstein, Sonja
Gómez-Bengoa, Enrique
Sotorríos, Lía
Font Bardia, Ma. Mercedes
Keywords: Estereoquímica
Issue Date: 3-Jan-2020
Publisher: American Chemical Society
Abstract: Simple treatment of chiral titanium(IV) enolates with diacyl peroxides produces highly diastereoselective decarboxylative alkylations to efficiently deliver the corresponding adducts, most of which are not accessible through any of the current alkylating procedures. Such an unprecedented alkylation proceeds through an SET process that triggers the decomposition of the peroxide into a carbon-centered radical that finally combines with the resulting Cα radical. The procedure has been applied to the enantioselective synthesis of arundic acid.
Note: Versió postprint del document publicat a:
It is part of: Organic Letters, 2020, vol. 22, num. 1, p. 199-203
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ISSN: 1523-7060
Appears in Collections:Articles publicats en revistes (Química Inorgànica i Orgànica)

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