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Title: | Modulation of the helical properties of DNA: next-to-nearest neighbour effects and beyond |
Author: | Balaceanu, Alexandra Buitrago Ospina, Diana Camila Walther, Jürgen Hospital, Adam Dans, Pablo D. Orozco López, Modesto |
Keywords: | Expressió gènica Gene expression |
Issue Date: | 8-Apr-2019 |
Publisher: | Oxford University Press |
Abstract: | We used extensive molecular dynamics simulations to study the structural and dynamic properties of the central d(TpA) step in the highly polymorphic d(CpTpApG) tetranucleotide. Contrary to the assumption of the dinucleotide-model and its nearest neighbours (tetranucleotide-model), the properties of the central d(TpA) step change quite significantly dependent on the next-to-nearest (hexanucleotide) sequence context and in a few cases are modulated by even remote neighbours (beyond next-to-nearest from the central TpA). Our results highlight the existence of previously undescribed dynamical mechanisms for the transmission of structural information into the DNA and demonstrate the existence of certain sequences with special physical properties that can impact on the global DNA structure and dynamics. |
Note: | Reproducció del document publicat a: https://doi.org/10.1093/nar/gkz255 |
It is part of: | Nucleic Acids Research, 2019, vol. 47, num. 9, p. 4418-4430 |
URI: | http://hdl.handle.net/2445/150222 |
Related resource: | https://doi.org/10.1093/nar/gkz255 |
ISSN: | 0305-1048 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona)) |
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