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http://hdl.handle.net/2445/151011
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DC Field | Value | Language |
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dc.contributor.author | Niñerola Baizán, Aida | - |
dc.contributor.author | Rojas, Santiago | - |
dc.contributor.author | Bonastre, Mercè | - |
dc.contributor.author | Tudela Fernández, Raúl | - |
dc.contributor.author | Lomeña Caballero, Francisco Juan | - |
dc.contributor.author | Pavía Segura, Javier | - |
dc.contributor.author | Marin, Concepció | - |
dc.contributor.author | Ros Puig, Domènec | - |
dc.date.accessioned | 2020-02-21T14:16:14Z | - |
dc.date.available | 2020-02-21T14:16:14Z | - |
dc.date.issued | 2015-02 | - |
dc.identifier.issn | 1555-4309 | - |
dc.identifier.uri | http://hdl.handle.net/2445/151011 | - |
dc.description.abstract | The 6-hydroxydopamine (6-OHDA) rodent model of Parkinson's disease (PD) has been used to evaluate the nigrostriatal pathway. The aim of this work was to explore the relationship between the degree of 6-OHDA-induced dopaminergic degeneration and [123 I]FP-CIT binding using single photon emission computed tomography (SPECT). Fourteen rats received a 6-OHDA injection (4 or 8 µg) into the left medial forebrain bundle. After 3 weeks, magnetic resonance imaging and scans with a small-animal SPECT system were performed. Finally, the nigrostriatal lesion was assessed by immunohistochemical analysis. Immunohistochemical analysis confirmed two levels of dopaminergic degeneration. Lesions induced by 6-OHDA diminished the ipsilateral [123 I]FP-CIT binding by 61 and 76%, respectively. The decrease in tracer uptake between control and lesioned animals was statistically significant, as was the difference between the two 6-OHDA lesioned groups. Results concluded that [123 I]FP-CIT SPECT is a useful technique to discriminate the degree of dopaminergic degeneration in a rat model of PD. | - |
dc.format.extent | 7 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley Hindawi Publishing | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1002/cmmi.1608 | - |
dc.relation.ispartof | Contrast Media & Molecular Imaging, 2015, vol. 10, num. 1, p. 67-73 | - |
dc.relation.uri | https://doi.org/10.1002/cmmi.1608 | - |
dc.rights | cc-by (c) Niñerola-Baizán, Aida et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biomedicina) | - |
dc.subject.classification | Malaltia de Parkinson | - |
dc.subject.classification | Tomografia computada per emissió de fotó simple | - |
dc.subject.other | Parkinson's disease | - |
dc.subject.other | Single-photon emission computed tomography | - |
dc.title | In vivo evaluation of the dopaminergic neurotransmission system using [123 I]FP-CIT SPECT in 6-OHDA lesioned rats | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 649402 | - |
dc.date.updated | 2020-02-21T14:16:14Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Biomedicina) Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques) Articles publicats en revistes (Fonaments Clínics) |
Files in This Item:
File | Description | Size | Format | |
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649402.pdf | 3.46 MB | Adobe PDF | View/Open |
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