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http://hdl.handle.net/2445/151382
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DC Field | Value | Language |
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dc.contributor.author | Carvajal-Vidal, Paulina | - |
dc.contributor.author | Mallandrich Miret, Mireia | - |
dc.contributor.author | García López, María Luisa | - |
dc.contributor.author | Calpena Campmany, Ana Cristina | - |
dc.date.accessioned | 2020-02-27T16:52:37Z | - |
dc.date.available | 2020-02-27T16:52:37Z | - |
dc.date.issued | 2017-11-21 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/2445/151382 | - |
dc.description.abstract | Halobetasol propionate (HB) is a potent synthetic corticosteroid used against inflammatory skin diseases, such as dermatitis, eczema, and psoriasis, among others. The aim of this study is to define how the presence of different skin penetration enhancers (nonane, menthone, limonene, azone, carene, decanol, linoleic acid and cetiol) affects the penetration and retention in skin of HB. To determine drug penetration through skin, 5% of each promoter was used in an ex vivo system with human skin on Franz cells. The results showed that the highest permeation occurs in the presence of menthone, followed by nonane. Permeation parameters were determined. The in vivo test was assessed, and the formulation containing HB-menthone presented better anti-inflammatory efficacy. These results are useful to generate a specific treatment according to each patient's needs, and the inflammatory characteristics of the disease. View Full-Text Keywords: halobetasol propionate; permeation enhancers; skin permeation; skin inflammation; topical corticosteroid | - |
dc.format.extent | 16 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/ijms18112475 | - |
dc.relation.ispartof | International Journal of Molecular Sciences, 2017, vol. 18, num. 11, p. 2475 | - |
dc.relation.uri | https://doi.org/10.3390/ijms18112475 | - |
dc.rights | cc-by (c) Carvajal-Vidal, Paulina et al., 2017 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) | - |
dc.subject.classification | Dermatitis | - |
dc.subject.classification | Permeabilitat | - |
dc.subject.classification | Corticosteroides | - |
dc.subject.other | Dermatitis | - |
dc.subject.other | Permeability | - |
dc.subject.other | Adrenocortical hormones | - |
dc.title | Effect of Different Skin Penetration Promoters in Halobetasol Propionate Permeation and Retention in Human Skin | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 678701 | - |
dc.date.updated | 2020-02-27T16:52:38Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 29160818 | - |
Appears in Collections: | Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB)) Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
Files in This Item:
File | Description | Size | Format | |
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678701.pdf | 2.33 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License