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http://hdl.handle.net/2445/152536
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DC Field | Value | Language |
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dc.contributor.author | Reyes-Chilpa, Ricardo | - |
dc.contributor.author | Berkov, Strahil | - |
dc.contributor.author | Hernández-Ortega, Simón | - |
dc.contributor.author | Jankowski, Christopher K. | - |
dc.contributor.author | Arseneau, Sebastien | - |
dc.contributor.author | Clotet-Codina, Imma | - |
dc.contributor.author | Esté, José A. | - |
dc.contributor.author | Codina Mahrer, Carles | - |
dc.contributor.author | Viladomat Meya, Francesc | - |
dc.contributor.author | Bastida Armengol, Jaume | - |
dc.date.accessioned | 2020-03-11T17:20:13Z | - |
dc.date.available | 2020-03-11T17:20:13Z | - |
dc.date.issued | 2011-11-15 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | http://hdl.handle.net/2445/152536 | - |
dc.description.abstract | The bulbs and aerial parts of Zephyranthes concolor (Lindl.) Benth. & Hook. f. (Amaryllidaceae), an endemic species to Mexico, were found to contain the alkaloids chlidanthine, galanthamine, galanthamine N-oxide, lycorine, galwesine, and epinorgalanthamine. Since currently only partial and low resolution 1H-NMR data for chlidanthine acetate are available, and none for chlidanthine, its 1D and 2D high resolution 1H- and 13C-NMR spectra were recorded. Unambiguous assignations were achieved with HMBC, and HSQC experiments, and its structure was corroborated by X-ray diffraction. Minimum energy conformation for structures of chlidanthine, and its positional isomer galanthamine, were calculated by molecular modelling. Galanthamine is a well known acetylcholinesterase inhibitor; therefore, the isolated alkaloids were tested for this activity. Chlidanthine and galanthamine N-oxide inhibited electric eel acetylcholinesterase (2.4 and 2.6 × 10−5 M, respectively), indicating they are about five times less potent than galanthamine, while galwesine was inactive at 10−3 M. Inhibitory activity of HIV-1 replication, and cytotoxicity of the isolated alkaloids were evaluated in human MT-4 cells; however, the alkaloids showed poor activity as compared with standard anti-HIV drugs, but most of them were not cytotoxic. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/molecules16119520 | - |
dc.relation.ispartof | Molecules, 2011, vol. 16, num. 11, p. 9520-9533 | - |
dc.relation.uri | https://doi.org/10.3390/molecules16119520 | - |
dc.rights | cc-by (c) Reyes-Chilpa, Ricardo et al., 2011 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) | - |
dc.subject.classification | Alcaloides | - |
dc.subject.classification | Amaril·lidàcies | - |
dc.subject.classification | Raigs X | - |
dc.subject.classification | VIH (Virus) | - |
dc.subject.other | Alkaloids | - |
dc.subject.other | Amaryllidaceae | - |
dc.subject.other | X-rays | - |
dc.subject.other | HIV (Viruses) | - |
dc.title | Acetylcholinesterase-inhibiting alkaloids from Zephyranthes concolor | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 602412 | - |
dc.date.updated | 2020-03-11T17:20:13Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 22086403 | - |
Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) |
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602412.pdf | 250.38 kB | Adobe PDF | View/Open |
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