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http://hdl.handle.net/2445/152583| Title: | Low-density lipoprotein (LDL)-antioxidant biflavonoids from Garcinia madruno |
| Author: | Osorio Durango, Edison Javier Londoño, Julián Bastida Armengol, Jaume |
| Keywords: | Gutíferes Antioxidants Flavonoides Glucòsids Guttiferae Antioxidants Flavonoids Glucosides |
| Issue Date: | 22-May-2013 |
| Publisher: | MDPI |
| Abstract: | Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE50 of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC50 = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant. |
| Note: | Reproducció del document publicat a: https://doi.org/10.3390/molecules18056092 |
| It is part of: | Molecules, 2013, vol. 18, num. 5, p. 6092-6100 |
| URI: | http://hdl.handle.net/2445/152583 |
| Related resource: | https://doi.org/10.3390/molecules18056092 |
| ISSN: | 1420-3049 |
| Appears in Collections: | Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica) |
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