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Title: Low-density lipoprotein (LDL)-antioxidant biflavonoids from Garcinia madruno
Author: Osorio Durango, Edison Javier
Londoño, Julián
Bastida Armengol, Jaume
Keywords: Gutíferes
Issue Date: 22-May-2013
Publisher: MDPI
Abstract: Six biflavonoids were isolated from G. madruno, one of which, 7''-O-(6''''-acetyl)-glucoside of morelloflavone, is a new compound identified on the basis of 1D, 2D NMR (HMQC and HMBC) spectroscopic methods and chemical evidence. The antioxidant activity of the biflavonoids against low-density lipoprotein (LDL) peroxidation induced with Cu2+, was studied by means of a TBARS assay. The antioxidant potential of a biflavonoid fraction (BF) was also evaluated and correlated with its biflavonoid content. The flavanone-(3→8'')-flavone biflavonoids displayed antioxidant activity, particularly morelloflavone, which was significantly more potent than quercetin, with a CE50 of 12.36 μg/mL. Lipid peroxidation, was also significantly reduced in the presence of the BF (EC50 = 11.85 μg/mL). These results suggest that the BF is an excellent antioxidant.
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It is part of: Molecules, 2013, vol. 18, num. 5, p. 6092-6100
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ISSN: 1420-3049
Appears in Collections:Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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