Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/152589
Title: | Alkaloids from Hippeastrum papilio |
Author: | Andrade, Jean Paulo de Berkov, Strahil Viladomat Meya, Francesc Codina Mahrer, Carles Zuanazzi, José Ângelo Silveira Bastida Armengol, Jaume |
Keywords: | Alcaloides Acetilcolinesterasa Malaltia d'Alzheimer Amaril·lidàcies Alkaloids Acetylcholinesterase Alzheimer's disease Amaryllidaceae |
Issue Date: | 18-Aug-2011 |
Publisher: | MDPI |
Abstract: | Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/molecules16087097 |
It is part of: | Molecules, 2011, vol. 16, num. 8, p. 7097-7104 |
URI: | http://hdl.handle.net/2445/152589 |
Related resource: | https://doi.org/10.3390/molecules16087097 |
ISSN: | 1420-3049 |
Appears in Collections: | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
602411.pdf | 438.38 kB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License