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Title: Alkaloids from Hippeastrum papilio
Author: Andrade, Jean Paulo de
Berkov, Strahil
Viladomat Meya, Francesc
Codina Mahrer, Carles
Zuanazzi, José Angelo S..
Bastida Armengol, Jaume
Keywords: Alcaloides
Malaltia d'Alzheimer
Alzheimer's disease
Issue Date: 18-Aug-2011
Publisher: MDPI
Abstract: Galanthamine, an acetylcholinesterase inhibitor marketed as a hydrobromide salt (Razadyne®, Reminyl®) for the treatment of Alzheimer's disease (AD), is obtained from Amaryllidaceae plants, especially those belonging to the genera Leucojum, Narcissus, Lycoris and Ungernia. The growing demand for galanthamine has prompted searches for new sources of this compound, as well as other bioactive alkaloids for the treatment of AD. In this paper we report the isolation of the new alkaloid 11β-hydroxygalanthamine, an epimer of the previously isolated alkaloid habranthine, which was identified using NMR techniques. It has been shown that 11β-hydroxygalanthamine has an important in vitro acetylcholinesterase inhibitory activity. Additionally, Hippeastrum papilio yielded substantial quantities of galanthamine.
Note: Reproducció del document publicat a:
It is part of: Molecules, 2011, vol. 16, num. 8, p. 7097-7104
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ISSN: 1420-3049
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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