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Title: Impact of Foods and Dietary Supplements Containing Hydroxycinnamic Acids on Cardiometabolic Biomarkers: A Systematic Review to Explore Inter-Individual Variability
Author: Martini, Daniela
Chiavaroli, Laura
González-Sarrías, Antonio
Bresciani, Letizia
Palma-Duran, Susana A.
Dall'Asta, Margherita
Deligiannidou, Georgia-Eirini
Massaro, Marika
Scoditti, Egeria
Combet, Emilie
Maksimova, Viktorija
Urpí Sardà, Mireia
Kontogiorgis, Christos A.
Andrés Lacueva, Ma. Cristina
Gibney, Eileen R.
Del Rio, Daniele
Morand, Christine
Garcia Aloy, Mar
Rodriguez-Mateos, Ana
Mena, Pedro
Keywords: Vegetarianisme
Compostos bioactius
Malalties cardiovasculars
Bioactive compounds
Cardiovascular diseases
Issue Date: 5-Aug-2019
Publisher: MDPI
Abstract: Plant-based diets rich in bioactive compounds such as polyphenols have been shown to positively modulate the risk of cardiometabolic (CM) diseases. The inter-individual variability in the response to these bioactives may affect the findings. This systematic review aimed to summarize findings from existing randomized clinical trials (RCTs) evaluating the effect of hydroxycinnamic acids (HCAs) on markers of CM health in humans. Literature searches were performed in PubMed and the Web of Science. RCTs on acute and chronic supplementation of HCA-rich foods/extracts on CM biomarkers were included. Forty-four RCTs (21 acute and 23 chronic) met inclusion criteria. Comparisons were made between RCTs, including assessments based on population health status. Of the 44 RCTs, only seven performed analyses on a factor exploring inter-individual response to HCA consumption. Results demonstrated that health status is a potentially important effect modifier as RCTs with higher baseline cholesterol, blood pressure and glycaemia demonstrated greater overall effectiveness, which was also found in studies where specific subgroup analyses were performed. Thus, the effect of HCAs on CM risk factors may be greater in individuals at higher CM risk, although future studies in these populations are needed, including those on other potential determinants of inter-individual variability. PROSPERO, registration number CRD42016050790.
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It is part of: Nutrients, 2019, vol. 11, num. 8, p. 1085
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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