Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/156462
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dc.contributor.authorRuschel Tallini, Luciana-
dc.contributor.authorTorras Claveria, Laura-
dc.contributor.authorBorges, Warley de Souza-
dc.contributor.authorKaiser, Marcel-
dc.contributor.authorViladomat Meya, Francesc-
dc.contributor.authorZuanazzi, José Ângelo Silveira-
dc.contributor.authorBastida Armengol, Jaume-
dc.date.accessioned2020-04-21T14:46:42Z-
dc.date.available2020-04-21T14:46:42Z-
dc.date.issued2018-05-26-
dc.identifier.issn1420-3049-
dc.identifier.urihttp://hdl.handle.net/2445/156462-
dc.description.abstractNatural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. In this study, twenty-three alkaloids were identified from Crinum amabile by GC-MS and two new structures (augustine N-oxide and buphanisine N-oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from C. amabile gave better results than the reference drugs, so it was possible to conclude that the N-oxide group does not increase their therapeutic potential.-
dc.format.extent11 p.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherMDPI-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.3390/molecules23061277-
dc.relation.ispartofMolecules, 2018, vol. 23, num. 6, p. 1277-
dc.relation.urihttps://doi.org/10.3390/molecules23061277-
dc.rightscc-by (c) Ruschel Tallini, Luciana et al., 2018-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es-
dc.sourceArticles publicats en revistes (Biologia, Sanitat i Medi Ambient)-
dc.subject.classificationProductes naturals-
dc.subject.classificationMedicaments-
dc.subject.classificationAmaril·lidàcies-
dc.subject.otherNatural products-
dc.subject.otherDrugs-
dc.subject.otherAmaryllidaceae-
dc.titleN-oxide alkaloids from Crinum amabile (Amaryllidaceae)-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.identifier.idgrec686972-
dc.date.updated2020-04-21T14:46:43Z-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid29861456-
Appears in Collections:Articles publicats en revistes (Biologia, Sanitat i Medi Ambient)

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