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Title: Leptin and EGF Supplementation Enhance the Immune System Maturation in Preterm Suckling Rats
Author: Grases Pintó, Blanca
Torres-Castro, Paulina
Marín-Morote, Lídia
Abril Gil, Maria del Mar
Castell, Margarida
Rodríguez Lagunas, María José
Pérez-Cano, Francisco J.
Franch i Masferrer, Àngels
Keywords: Infants prematurs
Sistema immunitari
Llet materna
Premature infants
Immune system
Breast milk
Issue Date: 6-Oct-2019
Publisher: MDPI
Abstract: In preterm newborns the immaturity of the immune system is remarkable, with reduced innate and adaptive immune responses. Many bioactive compounds in breast milk, such as growth factors and adipokines, contribute to the immune system's maturation in early life. However, studies on the immunoregulatory activity in preterm neonates are practically nonexistent. The aim of the present study was to determine whether a nutritional supplementation in early life with leptin or epidermal growth factor (EGF) was able to promote the maturation of the systemic and intestinal immune system in preterm conditions. For this purpose, premature rats were daily supplemented by oral gavage with leptin or EGF. Term and Preterm groups receiving vehicle were used as controls. Preterm rats showed deficiencies compared to full-term ones, such as lower body weights, erythrocyte counts, plasma IgG and IgM concentrations and B cell percentages, and higher values of Th and Tc TCRαβ+ cells in mesenteric lymph nodes, and intestinal permeability, among others. However, leptin and EGF supplementation were able to revert some of these deficiencies and to improve the premature immune system's development. These results suggest that leptin and EGF are involved in enhancing the maturation of the systemic and intestinal immune system in preterm conditions.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2019, vol. 11, num. 10, p. 2380
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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