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Title: Vestibular damage in chronic ototoxicity: a mini-review
Author: Sedó Cabezón, Lara
Soler-Martín, Carla
Llorens i Baucells, Jordi
Boadas i Vaello, Pere
Keywords: Agents antiinfecciosos
Cèl·lules acústiques
Malalties neurodegeneratives
Ressenyes sistemàtiques (Investigació mèdica)
Anti-infective agents
Hair cells
Neurodegenerative Diseases
Systematic reviews (Medical research)
Issue Date: 1-Jul-2014
Publisher: Elsevier B.V.
Abstract: Ototoxicity is a major cause of the loss of hearing and balance in humans. Ototoxic compounds include pharmaceuticals such as aminoglycoside antibiotics, anti-malarial drugs, loop diuretics and chemotherapeutic platinum agents, and industrial chemicals including several solvents and nitriles. Human and rodent data indicate that the main target of toxicity is hair cells (HCs), which are the mechanosensory cells responsible for sensory transduction in both the auditory and the vestibular system. Nevertheless, the compounds may also affect the auditory and vestibular ganglion neurons. Exposure to ototoxic compounds has been found to cause HC apoptosis, HC necrosis, and damage to the afferent terminals, of differing severity depending on the ototoxicity model. One major pathway frequently involved in HC apoptosis is the c-jun N-terminal kinase (JNK) signaling pathway activated by reactive oxygen species, but other apoptotic pathways can also play a role in ototoxicity. Moreover, little is known about the effects of chronic low-dose exposure. In rodent vestibular epithelia, extrusion of live HCs from the sensory epithelium may be the predominant form of cell demise during chronic ototoxicity. In addition, greater involvement of the afferent terminals may occur, particularly the calyx units contacting type I vestibular HCs. As glutamate is the neurotransmitter in this synapse, excitotoxic phenomena may participate in afferent and ganglion neuron damage. Better knowledge of the events that take place in chronic ototoxicity is of great interest, as it will increase understanding of the sensory loss associated with chronic exposure and ageing.
Note: Versió postprint del document publicat a:
It is part of: Neurotoxicology, 2014, vol. 43, p. 21-27
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ISSN: 0161-813X
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Fisiològiques)

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