Please use this identifier to cite or link to this item:
|Title:||Diet-Related Metabolites Associated with Cognitive Decline Revealed by Untargeted Metabolomics in a Prospective Cohort|
|Author:||Low, Dorrain Yanwen|
Lefèvre Arbogast, Sophie
Urpí Sardà, Mireia
Pujos Guillot, Estelle
Lucassen, Paul J.
Proust Lima, Cécile
Hejblum, Boris P.
Andrés Lacueva, Ma. Cristina
|Abstract:||Scope: Untargeted metabolomics may reveal preventive targets in cognitive aging, including within the food metabolome. Methods and results: A case-control study nested in the prospective Three-City study includes participants aged &65 years and initially free of dementia. A total of 209 cases of cognitive decline and 209 controls (matched for age, gen- der, education) with slower cognitive decline over up to 12 years are contrasted. Using untargeted metabolomics and bootstrap-enhanced penalized regression, a baseline serum signature of 22 metabolites associated with subsequent cognitive decline is identified. The signature includes three coffee metabolites, a biomarker of citrus intake, a cocoa metabolite, two metabolites putatively derived from fish and wine, three medium-chain acylcarnitines, glycodeoxycholic acid, lysoPC(18:3), trimethyllysine, glucose, cortisol, creatinine, and arginine. Adding the 22 metabolites to a reference predictive model for cognitive decline (conditioned on age, gender, education and including ApoE-ε4, diabetes, BMI, and number of medications) substantially increases the predictive performance: cross-validated Area Under the Receiver Operating Curve = 75% [95% CI 70-80%] compared to 62% [95% CI 56-67%]. Conclusions: The untargeted metabolomics study supports a protective role of specific foods (e.g., coffee, cocoa, fish) and various alterations in the endogenous metabolism responsive to diet in cognitive aging.|
|Note:||Versió postprint del document publicat a: https://doi.org/10.1002/mnfr.201900177|
|It is part of:||Molecular Nutrition & Food Research, 2019, vol. 63, p. 1900177|
|Appears in Collections:||Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.