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http://hdl.handle.net/2445/158574
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DC Field | Value | Language |
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dc.contributor.author | Zamudio Vázquez, Rubí | - |
dc.contributor.author | Ivanova, Saska | - |
dc.contributor.author | Moreno, Miguel | - |
dc.contributor.author | Hernández-Alvarez, María Isabel | - |
dc.contributor.author | Giralt Lledó, Ernest | - |
dc.contributor.author | Bidon-Chanal Badia, Axel | - |
dc.contributor.author | Zorzano Olarte, Antonio | - |
dc.contributor.author | Albericio Palomera, Fernando | - |
dc.contributor.author | Tulla-Puche, Judit | - |
dc.date.accessioned | 2020-05-04T15:37:33Z | - |
dc.date.available | 2020-05-04T15:37:33Z | - |
dc.date.issued | 2015-05-20 | - |
dc.identifier.issn | 2041-6520 | - |
dc.identifier.uri | http://hdl.handle.net/2445/158574 | - |
dc.description.abstract | The synthesis of a new small library of quinoxaline-containing peptides is described. After cytotoxic evaluation in four human cancer cell lines, as well as detailed biological studies, it was found that the most active compound, RZ2, promotes the formation of acidic compartments, where it accumulates, blocking the progression of autophagy. Further disruption of the mitochondrial membrane potential and an increase in mitochondrial ROS was observed, causing cells to undergo apoptosis. Given its cytotoxic activity and protease-resistant features, RZ2 could be a potential drug candidate for cancer treatment and provide a basis for future research into the crosstalk between autophagy and apoptosis and its relevance in cancer therapy. | - |
dc.format.extent | 13 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Royal Society of Chemistry | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1039/C5SC00125K | - |
dc.relation.ispartof | Chemical Science, 2015, num. 6, p. 4537-4549 | - |
dc.relation.uri | https://doi.org/10.1039/C5SC00125K | - |
dc.rights | cc-by (c) Zamudio Vázquez, Rubí et al., 2015 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es/ | * |
dc.source | Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) | - |
dc.subject.classification | Quinoxalina | - |
dc.subject.classification | Pèptids | - |
dc.subject.classification | Oncologia | - |
dc.subject.classification | Ressonància magnètica nuclear | - |
dc.subject.classification | Síntesi en fase sólida | - |
dc.subject.classification | Química combinatòria | - |
dc.subject.other | Quinoxalines | - |
dc.subject.other | Peptides | - |
dc.subject.other | Oncology | - |
dc.subject.other | Nuclear magnetic resonance | - |
dc.subject.other | Solid-phase synthesis | - |
dc.subject.other | Combinatorial chemistry | - |
dc.title | A new quinoxaline-containing peptide induces apoptosis in cancer cells by autophagy modulation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 653036 | - |
dc.date.updated | 2020-05-04T15:37:33Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia) |
Files in This Item:
File | Description | Size | Format | |
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653036.pdf | 4.39 MB | Adobe PDF | View/Open |
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