Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/158701
Title: | Thymidine- and AZT-linked 5-(1,3-dioxoalkyl)tetrazoles and 4-(1,3-dioxoalkyl)-1,2,3-triazoles |
Author: | Bosch Hereu, Lluís Delelis, Olivier Subra, Frédéric Deprez, Eric Witvrow, Myriam Vilarrasa i Llorens, Jaume |
Keywords: | VIH (Virus) Inhibidors de la integrasa Integrase inhibitors HIV (Viruses) |
Issue Date: | 1-Mar-2012 |
Publisher: | Elsevier Ltd |
Abstract: | N3 of thymidine and of 3′-azido-3′-deoxythymidine (AZT) has been linked to a tetrazole ring by condensation of nucleoside-derived 2-oxonitriles with the lithium salt of 5-acetyl-1-(4-fluorobenzyl)tetrazole (obtained by a 'click' reaction). 4-Acetyl-1,2,3-triazole, also prepared by a Cu-catalysed cycloaddition, has been similarly linked. A route for the conjugation of NRTIs with pharmacophoric elements of integrase inhibitors (INIs) has thus been disclosed. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.tetlet.2011.11.079 |
It is part of: | Tetrahedron Letters, 2012, vol. 53, num. 3, p. 514-518 |
URI: | http://hdl.handle.net/2445/158701 |
Related resource: | https://doi.org/10.1016/j.tetlet.2011.11.079 |
ISSN: | 0040-4039 |
Appears in Collections: | Articles publicats en revistes (Química Inorgànica i Orgànica) |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
611183.pdf | 548.21 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.