Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/158943
Title: Role of HDL function and LDL atherogenicity on cardiovascular risk: A comprehensive examination
Author: Hernáez Camba, Álvaro
Soria Florido, María Trinidad
Schröder, Helmut, 1958-
Ros Rahola, Emilio
Pintó Sala, Xavier
Estruch Riba, Ramon
Salas Salvadó, Jordi
Corella Piquer, Dolores
Arós, Fernando
Serra Majem, Lluís
Martínez-González, Miguel Ángel, 1957-
Fiol Sala, Miguel
Lapetra, José
Elosua, Roberto
Lamuela Raventós, Rosa Ma.
Fitó Colomer, Montserrat
Keywords: Colesterol
Lipoproteïnes
Oxidació
Cholesterol
Lipoproteins
Oxidation
Issue Date: 2019
Publisher: Public Library of Science (PLoS)
Abstract: Background High-density lipoprotein (HDL) functionality and low-density lipoprotein (LDL) atherogenic traits can describe the role of both particles on cardiovascular diseases more accurately than HDL- or LDL-cholesterol levels. However, it is unclear how these lipoprotein properties are particularly affected by different cardiovascular risk factors. Objective To determine which lipoprotein properties are associated with greater cardiovascular risk scores and each cardiovascular risk factor. Methods In two cross-sectional baseline samples of PREDIMED trial volunteers, we assessed the associations of HDL functionality (N = 296) and LDL atherogenicity traits (N = 210) with: 1) the 10-year predicted coronary risk (according to the Framingham-REGICOR score), and 2) classical cardiovascular risk factors. Results Greater cardiovascular risk scores were associated with low cholesterol efflux values; oxidized, triglyceride-rich, small HDL particles; and small LDLs with low resistance against oxidation (P-trend<0.05, all). After adjusting for the rest of risk factors; 1) type-2 diabetic individuals presented smaller and more oxidized LDLs (P<0.026, all); 2) dyslipidemic participants had smaller HDLs with an impaired capacity to metabolize cholesterol (P<0.035, all); 3) high body mass index values were associated to lower HDL and LDL size and a lower HDL capacity to esterify cholesterol (P<0.037, all); 4) men presented a greater HDL oxidation and lower HDL vasodilatory capacity (P<0.046, all); and 5) greater ages were related to small, oxidized, cytotoxic LDL particles (P<0.037, all). Conclusions Dysfunctional HDL and atherogenic LDL particles are present in high cardiovascular risk patients. Dyslipidemia and male sex are predominantly linked to HDL dysfunctionality, whilst diabetes and advanced age are associated with LDL atherogenicity. © 2019 Hernáez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Note: Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0218533
It is part of: PLoS One, 2019, vol. 14, num. 6, p. e0218533
URI: http://hdl.handle.net/2445/158943
Related resource: https://doi.org/10.1371/journal.pone.0218533
ISSN: 1932-6203
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)
Articles publicats en revistes (Ciències Clíniques)

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