Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/161866
Title: Addition of hyaluronic acid improves tlerance to 7% hypertonic saline solution in bronchiectasis patients.
Author: Máiz, Luis
Girón, Rosa M.
Prats, E.
Clemente, Marta G.
Polverino, Eva
Caño, Silvia
Cordovilla, Rosa
Dorca i Sargatal, Jordi
Peñalver, Carlos
Baranda, Félix
Martínez García, Miguel Ángel
Keywords: Infeccions respiratòries
Malalties pulmonars obstructives cròniques
Respiratory infections
Chronic obstructive pulmonary diseases
Issue Date: Jan-2018
Publisher: SAGE Publications
Abstract: Background: The excessive retention of sputum in the airways, leading to pulmonary infections, is a common consequence of bronchiectasis. Although inhalation of 7% hypertonic saline (HS) has proven an effective method to help remove the mucus, many patients are intolerant of this treatment. The addition of 0.1% hyaluronic acid to HS (HS+HA) could increase tolerance to HS in these patients. The main objective of this study was to evaluate the tolerability of HS+HA in bronchiectasis patients who are intolerant to HS. Methods: This prospective, observational, open-label study analysed the outcomes of two groups of bronchiectasis patients previously scheduled to start HS therapy. Patients were assessed for tolerance to HS by a questionnaire, spirometry and clinical evaluation. Patients who were intolerant were evaluated for tolerance to HS+HA approximately one week later. All patients were evaluated for their tolerance to HS or HS+HA 4 weeks after the start of their treatment. Patients were also assessed with quality-of-life and adherence questionnaires, and all adverse events were registered. Results: A total of 137 bronchiectasis patients were enrolled in the study (age = 63.0 ± 14.7 years; 63.5% women). Of these, 92 patients (67.1%) were tolerant and 45 patients (32.9%) were intolerant to HS. Of the 45 patients intolerant to HS, 31 patients (68.9%) were tolerant and 14 patients (31.1%) intolerant to HS+HA. Of these 31 tolerant patients, 26 (83.9%) could complete the 4-week treatment with HS+HA. Conclusions: Two-thirds of bronchiectasis patients that presented intolerance to inhaled HS alone are tolerant to inhaled HS+HA, suggesting that HA improves tolerance to HS therapy.
Note: Reproducció del document publicat a: https://doi.org/10.1177/1753466618787385
It is part of: Therapeutic Advances In Respiratory Disease, 2018, vol. 12, p. 1-10
URI: http://hdl.handle.net/2445/161866
Related resource: https://doi.org/10.1177/1753466618787385
ISSN: 1753-4658
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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