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http://hdl.handle.net/2445/162772
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DC Field | Value | Language |
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dc.contributor.author | Steyn, Angela | - |
dc.contributor.author | Crowther, Nigel J. | - |
dc.contributor.author | Norris, Shane A. | - |
dc.contributor.author | Rabionet Janssen, Raquel | - |
dc.contributor.author | Estivill, Xavier, 1955- | - |
dc.contributor.author | Ramsay, Michèle | - |
dc.date.accessioned | 2020-05-28T09:43:34Z | - |
dc.date.available | 2020-10-04T05:10:23Z | - |
dc.date.issued | 2019-10-04 | - |
dc.identifier.issn | 1750-1911 | - |
dc.identifier.uri | http://hdl.handle.net/2445/162772 | - |
dc.description.abstract | Aim: Gestational diabetes mellitus (GDM) has been linked with adverse long-term health outcomes for the fetus and mother. These effects may be mediated by epigenetic modifications. Materials & methods: Genome-wide RNA sequencing was performed in placental tissue and maternal blood in six GDM and six non-GDM pregnancies. Promoter region DNA methylation was examined for selected genes and correlated with gene expression to examine an epigenetic modulator mechanism. Results: Reductions of mRNA expression and increases in promoter methylation were observed for G6PD in GDM women, and for genes encoding IGF-binding proteins in GDM-exposed placenta. Conclusion: GDM involves epigenetic attenuation of G6PD, which may lead to hyperglycemia and oxidative stress, and the IGF-axis, which may modulate fetal macrosomia. | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Future Medicine | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.2217/epi-2018-0206 | - |
dc.relation.ispartof | Epigenomics, 2019, vol. 11, num. 12 | - |
dc.relation.uri | https://doi.org/10.2217/epi-2018-0206 | - |
dc.rights | (c) Future Medicine, 2019 | - |
dc.source | Articles publicats en revistes (Genètica, Microbiologia i Estadística) | - |
dc.subject.classification | Diabetis en l'embaràs | - |
dc.subject.classification | Epigenètica | - |
dc.subject.other | Diabetes in pregnancy | - |
dc.subject.other | Epigenetics | - |
dc.title | Epigenetic modification of the pentose phosphate pathway and the IGF-axis in women with gestational diabetes mellitus | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 692444 | - |
dc.date.updated | 2020-05-28T09:43:35Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Genètica, Microbiologia i Estadística) |
Files in This Item:
File | Description | Size | Format | |
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692444.pdf | 1.32 MB | Adobe PDF | View/Open |
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