Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/163112
Title: Alterations in the innate immune system due to exhausting exercise in intensively trained rats
Author: Estruel Amades, Seila
Camps Bossacoma, Mariona
Massot Cladera, Malen
Pérez-Cano, Francisco J.
Castell, Margarida
Keywords: Sistema immunitari
Exercici
Immune system
Exercise
Issue Date: 2020
Publisher: Nature Publishing Group
Abstract: It is known that intensive physical activity alters the immune system's functionality. However, the influence of the intensity and duration of exercise needs to be studied in more depth. We aimed to establish the changes in the innate immune response induced by two programmes of intensive training in rats compared to sedentary rats. A short training programme included 2 weeks of intensive training, ending with an exhaustion test (short training with exhaustion, S-TE). A second training programme comprised 5-week training including two exhaustion tests and three trainings per week. In this case, immune status was assessed before (T), immediately after (TE) and 24 h after (TE24) an additional final exhaustion test. Biomarkers such as phagocytic activity, macrophage cytokine and reactive oxygen species (ROS) production, and natural killer (NK) cell activity were quantified. S-TE was not enough to induce changes in the assessed innate immunity biomarkers. However, the second training was accompanied by a decrease in the phagocytic activity, changes in the pattern of cytokine secretion and ROS production by macrophages and reduced NK cell proportion but increased NK cytotoxic activity. In conclusion, a 5-week intense training programme, but not a shorter training, induced alterations in the innate immune system functionality.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41598-020-57783-4
It is part of: Scientific Reports, 2020, vol. 10, num. 1, p. 967
URI: http://hdl.handle.net/2445/163112
Related resource: https://doi.org/10.1038/s41598-020-57783-4
ISSN: 2045-2322
Appears in Collections:Articles publicats en revistes (Bioquímica i Fisiologia)

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