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Title: The brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids
Author: Paulo de Andrade, Jean
Giordani, R. B.
Torras Claveria, Laura
Pigni, Natalia Belén
Berkov, Strahil
Font Bardia, Ma. Mercedes
Calvet Pallàs, Maria Teresa
Konrath, E.
Bueno, K.
Sachett, L. G.
Dutilh, J. H.
Borges, W. D.
Viladomat Meya, Francesc
Henriques, A. T.
Nair, Jerald J.
Zuanazzi, J. A. S.
Bastida Armengol, Jaume
Keywords: Alcaloides
X-ray crystallography
Issue Date: Feb-2016
Publisher: Springer Science + Business Media
Abstract: Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glau-cescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crys-tallographic data for four galanthamine-type com-pounds revealed significant differences in the orientation of theN-methyl group, which are shown to be related to AChE inhibition.
Note: Versió postprint del document publicat a:
It is part of: Phytochemistry Reviews, 2016, vol. 15, num. 1, p. 147-160
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ISSN: 1568-7767
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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