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Title: Optimization of Xanthatin Extraction from Xanthium spinosum L. and its cytotoxic, anti-angiogenesis and antiviral properties
Author: Romero, M.
Zanuy, M.
Rosell, E.
Cascante i Serratosa, Marta
Piulats, J.
Font Bardia, Ma. Mercedes
Balzirini, J.
de Clercq, E.
Pujol Dilmé, M. Dolors
Keywords: Plantes medicinals
Medicaments antivírics
Medicinal plants
Antiviral agents
X-ray crystallography
Issue Date: 27-Jan-2015
Publisher: Elsevier Masson SAS
Abstract: The aqueous extraction of the sesquiterpene lactone xanthatin from Xanthium spinosum L. favours the conversion of xanthinium to xanthatin via the loss of acetic acid. The cytotoxic (Hep-G2 and L1210 human cell lines) and antiviral activities of isolated xanthatin are established. This natural compound shows significant cytotoxicity against the Hep-G2 cell line and our experimental results reveal its strong anti-angiogenesis capacity in vitro. The structure of xanthatin is determined by spectroscopic methods and for the first time confirmed by X-ray diffraction.
Note: Versió postprint del document publicat a:
It is part of: European Journal of Medicinal Chemistry, 2015, vol. 90, p. 491-496
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ISSN: 0223-5234
Appears in Collections:Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

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