Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/166226
Title: | Extraordinary cancer epigenomics: thinking outside the classical coding and promoter box |
Author: | Murtha, Matthew Esteller, Manel |
Keywords: | Epigènesi Càncer Genètica Epigenesis Cancer Genetics |
Issue Date: | 1-Oct-2016 |
Publisher: | Elsevier |
Abstract: | The advent of functional genomics powered by high-throughput sequencing has given us a new appreciation of the genomic sequences that lie outside the canonical promoter-coding sequence box. These regions harbor distant regulatory elements, enhancers, super-enhancers, insulators, alternative promoters, and sequences that transcribe as noncoding RNAs (ncRNAs) such as miRNAs and long ncRNAs. These functional genomics studies have also enabled a clearer understanding of the role of the 3D structure of the genome in epigenetic regulation. Here we review the impact that epigenetic changes, and specifically DNA methylation, have on these extraordinary sequences in driving cancer progression. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1016/j.trecan.2016.08.004 |
It is part of: | Trends in Cancer, 2016, vol. 2, num. 10, p. 572-584 |
URI: | http://hdl.handle.net/2445/166226 |
Related resource: | https://doi.org/10.1016/j.trecan.2016.08.004 |
ISSN: | 2405-8033 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Fisiològiques) |
Files in This Item:
File | Description | Size | Format | |
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669660.pdf | 1.85 MB | Adobe PDF | View/Open |
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