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http://hdl.handle.net/2445/166323
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DC Field | Value | Language |
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dc.contributor.author | Bianco, Valentino | - |
dc.contributor.author | Franzese, Giancarlo | - |
dc.contributor.author | Coluzza, Ivan | - |
dc.date.accessioned | 2020-06-19T08:50:13Z | - |
dc.date.available | 2020-11-13T06:10:28Z | - |
dc.date.issued | 2019-11-13 | - |
dc.identifier.issn | 1439-4235 | - |
dc.identifier.uri | http://hdl.handle.net/2445/166323 | - |
dc.description.abstract | We present a computational study on the folding and aggregation of proteins in an aqueous environment, as a function of its concentration. We show how the increase of the concentration of individual protein species can induce a partial unfolding of the native conformation without the occurrence of aggregates. A further increment of the protein concentration results in the complete loss of the folded structures and induces the formation of protein aggregates. We discuss the effect of the protein interface on the water fluctuations in the protein hydration shell and their relevance in the protein‐protein interaction. | - |
dc.format.extent | 8 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Wiley-VCH | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1002/cphc.201900904 | - |
dc.relation.ispartof | Chemphyschem, 2019, vol. 21, num. 5, p. 377-384 | - |
dc.relation.uri | https://doi.org/10.1002/cphc.201900904 | - |
dc.rights | (c) Wiley-VCH, 2019 | - |
dc.source | Articles publicats en revistes (Física de la Matèria Condensada) | - |
dc.subject.classification | Conformació de proteïnes | - |
dc.subject.classification | Biologia d'aigua dolça | - |
dc.subject.other | Proteins conformation | - |
dc.subject.other | Freshwater biology | - |
dc.title | In silico evidence that protein unfolding is as a precursor of the protein aggregation | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 702107 | - |
dc.date.updated | 2020-06-19T08:50:13Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/748170/EU//ProFrost | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Física de la Matèria Condensada) |
Files in This Item:
File | Description | Size | Format | |
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702107.pdf | 5.59 MB | Adobe PDF | View/Open |
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