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Title: Development, cytotoxicity and eye irritation profile of a new sunscreen formulation based on benzophenone-3-poly(ε-caprolactone) nanocapsules.
Author: Barbosa, Thallysson Carvalho
Dias Nascimento, Lívia Éven
Bani, Cristiane
Almeida, Taline
Nery, Marcelo
Santos, Rafael Silva
de Oliveira Menezes, Luana Renyelle
Zielinska, Aleksandra
Fernandes, Ana Rita
Cordeiro Cardoso, Juliana
Jäguer, Alessandro
Jäguer, Eliezer
Sánchez-López, E. (Elena)
Nalone, Luciana
Barbosa Souto, Eliana
Severino, Patrícia
Keywords: Toxicologia experimental
Protectors solars
Experimental toxicology
Sunscreens (Cosmetics)
Issue Date: 22-Sep-2019
Publisher: MDPI
Abstract: The objective of this work was to characterize the toxicological profile of a newly developed sunscreen formulation based on polymeric nanocapsules (NCs) loading benzophenone-3 (BZP3). NCs composed of poly(ε-caprolactone) carrot oil and Pluronic® F68 were produced by emulsification-diffusion method. Their mean particle size (Z-Ave) ranged from 280 to 420 nm, polydispersity index (PDI) was below 0.37, while zeta potential (ZP) reached about |+11 mV|. No cytotoxic effects were observed in L929 fibroblast cell line for the blank (i.e., non-loaded) NCs and BZP3-loaded NCs (BZP3-NCs). The semi-solid sunscreen formulation was stable over time (centrifugation testing) and exhibited non-Newtonian pseudoplastic behavior, which is typical of products for topical application onto the skin. The sun protection factor (SPF) value reached 8.84, when incorporating BZP3-NCs (SPF of 8.64) into the semi-solid formulation. A synergistic effect was also observed when combining the formulation ingredients of nanocapsules, i.e., SPF of carrot oil was 6.82, blank NCs was 6.84, and BZP3-loaded NCs was 8.64. From the hen's egg-chorioallantoic membrane test (HET-CAM) test, the non-irritation profile of the developed formulations could also be confirmed. The obtained results show a promising use of poly(ε-caprolactone) nanocapsules to be loaded with lipophilic sunscreens as benzophenone-3
Note: Reproducció del document publicat a:
It is part of: Toxics, 2019, vol. 7, num. 4, p. 51
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ISSN: 2305-6304
Appears in Collections:Articles publicats en revistes (Institut de Nanociència i Nanotecnologia (IN2UB))
Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)

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