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http://hdl.handle.net/2445/168599
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DC Field | Value | Language |
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dc.contributor.author | Sala Gaston, Joan | - |
dc.contributor.author | Martinez-Martinez, Arturo | - |
dc.contributor.author | Pedrazza, Leonardo | - |
dc.contributor.author | Lorenzo-Martín, L. Francisco | - |
dc.contributor.author | Caloto, Rubén | - |
dc.contributor.author | Bustelo, Xosé R. | - |
dc.contributor.author | Ventura Pujol, Francesc | - |
dc.contributor.author | Rosa López, José Luis | - |
dc.date.accessioned | 2020-07-14T11:46:58Z | - |
dc.date.available | 2020-07-14T11:46:58Z | - |
dc.date.issued | 2020-06-22 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | http://hdl.handle.net/2445/168599 | - |
dc.description.abstract | HERC proteins are ubiquitin E3 ligases of the HECT family. The HERC subfamily is composed of six members classified by size into large (HERC1 and HERC2) and small (HERC3-HERC6). HERC family ubiquitin ligases regulate important cellular processes, such as neurodevelopment, DNA damage response, cell proliferation, cell migration, and immune responses. Accumulating evidence also shows that this family plays critical roles in cancer. In this review, we provide an integrated view of the role of these ligases in cancer, highlighting their bivalent functions as either oncogenes or tumor suppressors, depending on the tumor type. We include a discussion of both the molecular mechanisms involved and the potential therapeutic strategies. | - |
dc.format.extent | 14 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cancers12061653 | - |
dc.relation.ispartof | Cancers, 2020, vol. 12, num. 6, p. E1653 | - |
dc.relation.uri | https://doi.org/10.3390/cancers12061653 | - |
dc.rights | cc-by (c) Sala Gaston, Joan et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Ciències Fisiològiques) | - |
dc.subject.classification | Genomes | - |
dc.subject.classification | Oncogens | - |
dc.subject.classification | Proteïnes supressores de tumors | - |
dc.subject.other | Genomes | - |
dc.subject.other | Oncogenes | - |
dc.subject.other | Tumor suppressor protein | - |
dc.title | HERC ubiquitin ligases in cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 702470 | - |
dc.date.updated | 2020-07-14T11:46:58Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32580485 | - |
Appears in Collections: | Articles publicats en revistes (Ciències Fisiològiques) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
Files in This Item:
File | Description | Size | Format | |
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702470.pdf | 1.47 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License