Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/171263
Title: Shared heritability and functional enrichment across six solid cancers
Author: Jiang, Xia
Finucane, Hilary K.
Schumacher, Fredrick R.
Schmit, Stephanie L.
Tyrer, Jonathan P.
Han, Younghun
Michailidou, Kyriaki
Lesseur, Corina
Kuchenbaecker, Karoline B.
Dennis, Joe
Conti, David V.
Goodman, Marc T.
Kelemen, Linda E.
Van Nieuwenhuysen, Els
Schmidt, Marjanka K.
Figueiredo, Jane C.
Nussbaum, Robert L.
Zorn, Kristin K.
Arnold, Susanne M.
Radice, Paolo
Fostira, Florentia
Chanock, Stephen J.
Wichmann, H-Erich
Gaudet, Mia M.
Burwinkel, Barbara
Thibodeau, Stephen N.
Saxena, Richa
Hulick, Peter J.
White, Emily
Tajara, Eloiza H.
Butzow, Ralf
Beckmann, Matthias W.
Rossing, Mary Anne
Shen, Hongbing
Sundfeldt, Karin
Lester, Jenny
Dwek, Miriam
Grankvist, Kjell
Setiawan, V. Wendy
Brook, Mark N.
Rennert, Hedy S.
Lindo, Noralane M.
Lam, Stephan
Teare, M. Dawn
Sandler, Dale P.
van Rensburg, Elizabeth J.
Levine, Douglas A.
Sutphen, Rebecca
Isaacs, Claudine
Zheng, Wei
Campbell, Peter T.
Olshan, Andrew F.
Modugno, Francesmary
Ramu, Susan J.
James, Paul
Cox, Angela
Wang, Qin
Carvalho, André L.
Lambrechts, Diether
Antonenkova, Natalia N.
Andrew, Angeline S.
Johansson, Mikael
Johansson, Mattias
Herrero, Rolando
Håkansson, Niclas
Berndt, Sonja I.
Lejbkowicz, Flavio
Moreno Aguado, Víctor
Gruber, Stephen B.
Gronberg, Henrik
Kristensen, Vessela N.
Sieh, Weiva
Joshi, Amit D.
Olah, Edith
Zienolddiny, Shanbeh
Vega, Ana
Campbell, Ian
Hall, Per
Rennert, Gad
Dunning, Alison M.
Osorio, Ana
Hoffmeister, Michael
Spurdle, Amanda B.
Marchand, Loïc Le
Buchanan, Daniel D.
Hamann, Ute
Caporaso, Neil E.
Fortner, Renée T.
Penney, Kathryn L.
Jenkins, Mattias
Tardón, Adonina
Kupryjanczyk, Jolanta
Kibel, Adam S.
Weissler, Mark C.
Terry, Kathryn L.
Ness, Andrew R.
Nevanlinna, Heli
Liu, Geoffrey
Lee, Eunjung
Barnes, Daniel R.
Miller, Austin
Tischkowitz, Marc
McKay, James D.
Raskin, Leon
Bojesen, Stig E.
Haugen, Aage
Nielsen, Finn C.
Swerdlow, Anthony J.
Mulligan, Anna Marie
Chang-Claude, Jenny
Weitzel, Jeffrey N.
Godwin, Andrew K.
Lacko, Martin
Khusnutdinova, Elza
Franceschi, Silvia
Brunet, Joan
Milne, Roger L.
Simard, Jacques
Hamilton, Robert J.
Kühl, Tabea
Christiani, David C.
Muir, Kenneth
West, Catharine M. L.
Lesse, Davor
Kjaer, Susanne K.
Bickeböller, Heike
Mucci, Lorelei
Jakubowska, Anna
Nikitina-Zake, Liene
Loupakis, Fotios
Wu, Anna H.
Pashayan, Nora
Risch, Angela
Maier, Christiane
Khaw, Kay-Tee
Southey, Melissa C.
Townsend, Paul A.
Thomas, Duncan
Vachon, Celine M.
Eccles, Diana M.
Kote-Jarai, Zsofia
Huyghe, Jeroen R.
May, Taymaa
Houlston, Richard
Fasching, Peter A.
Kim, Jeri
Prokofyeva, Darya
Giles, Graham G.
Karlan, Beth Y.
Antoniou, Antonis C.
Kiemeney, Lambertus A.
Bogdanova, Natalia V.
Guénel, Pascal
Gronwald, Jacek
Brennan, Paul
Batra, Jyotsna
Lindblom, Annika
Amos, Christopher I.
Leslie, Goska
Thomassen, Mads
Al Olama, Ali Amin
Pring, Miranda
Benitez, Javier
Cancel-Tassin, Géraldine
Price, Alkes L.
Woods, Michael
Tworoger, Shelley S.
Nathanson, Katherine L.
Teixeira, Manuel R.
Saloustros, Emmanouil
Newcomb, Polly A.
Cunningham, Julie M.
John, Esther M.
Couch, Fergus J.
Bolla, Manjeet K.
Casey, Graham
Goodman, Gary
Evans, D. Gareth
Riggan, Marjorie J.
Kaneva, Radka
Offit, Kenneth
Wu, Xifeng
Newcomb, Lisa F.
Stevens, Victoria L.
Singer, Christian F.
Lane, Jacqueline M.
Koutros, Stella
Lenz, Heinz-Josef
Phelan, Catherine M.
Edlund, Christopher K.
Pasaniuc, Bogdan
Pharoah, Paul D. P.
Gayther, Simon A.
Slattery, Martha L.
Torres, Diana
Schabath, Matthew B.
Andrulis, Irene L.
Duell, Eric J.
Kogevinas, Manolis
Benlloch, Sara
Ruyck, Kim De
Olsson, Håkan
Arun, Banu K.
Aronson, Kristan J.
Caligo, Maria A.
Ingles, Sue Ann
Hsu, Li
Rosenstein, Barry S.
Chenevix-Trench, Georgia
Claes, Kathleen B. M.
Nordestgaard, Børge G.
Cadoni, Gabriella
Diez, Orland
Ferris, Robert L.
Stefansson, Kari
Cannon-Albright, Lisa A.
Weinberg, Clarice R.
McGuffog, Lesley
Mannermaa, Arto
Neuhausen, Susan L.
Goldberg, Mark S.
Greene, Mark H.
Maehle, Lovise
Yannoukakos, Drakoulis
Garber, Judy
Webb, Penelope M.
Pejovic, Tanja
Toland, Amanda E.
Huntsman, David G.
Dörk, Thilo
Hong, Yun-Chul
Whittemore, Alice S.
Hung, Rayjean J.
García-Closas, Montserrat
Li, Li
Friedman, Eitan
Wolk, Alicja
Olopade, Olufunmilayo I.
Risch, Harvey A.
Hamdy, Freddie C.
Brauch, Hiltrud
Parsons, Michael T.
Tangen, Catherine M.
Middha, Pooja
Terry, Mary Beth
Stanford, Janet L.
Kraft, Peter
Montagna, Marco
Brenton, James D.
Roobol, Monique J.
Hampe, Jochen
Lubiński, Jan
Tung, Nadine
Stone, Jennifer
Brenner, Hermann
Neal, David E.
Pandha, Hardev
Sorensen, Karina Dalsgaard
Caldés, Trinidad
Boccia, Stefania
Stintzing, Sebastian
Weinstein, Stephanie
Chan, Andrew T.
Claessens, Frank
Eeles, Rosalind A.
Haiman, Christopher A.
Ellberg, Carolina
Margolin, Sara
Schleutker, Johanna
Park, Jong Y.
Knight, Julia A.
Cruz Correa, Marcia
Wiklund, Fredrik
Bandera, Elisa V.
Siegel, Erin M.
Le, Nhu D.
Taylor, Jack A.
Donovan, Jenny L.
Landi, Maria Teresa
Aldrich, Melinda C.
Velez Edwards, Digna R.
Easton, Douglas F.
Berchuck, Andrew
Devilee, Peter
Heitz, Florian
Hopper, John L.
Hunter, David J.
Peters, Ulrike
Albanes, Jeroen R.
Woll, Penella
García-Sáenz, José A.
Liloglou, Triantafillos
Phipps, Amanda I.
Cybulski, Cezary
Li, Christopher I.
Lazarus, Philip
Sawyer, Elinor J.
Meindl, Alfons
Peters, Wilbert H. M.
Goode, Ellen L.
Barkardottir, Rosa B.
Bien, Stephanie A.
Ulrich, Cornelia M.
Brunnström, Hans
Goldgar, David E.
Fletcher, Olivia
Moysich, Kirsten B.
Høgdall, Estrid
Gallinger, Steven J.
Chen, Chu
Elías Aguado-Barrera, Miguel
Imyanitov, Evgeny N.
Clements, Judith
MacInnis, Robert J.
Idos, Gregory
Daly, Mary B.
Anton-Culver, Hoda
Winqvist, Robert
Diergaarde, Brenda
Collée, J. Margriet
Bjørge, Line
Usmani, Nawaid
deFazio, Anna
Czene, Kamila
Ganz, Patricia A.
Campa, Daniele
Lindström, Sara
Ziogas, Argyrios
Plaseska-Karanfilska, Dijana
Gago-Dominguez, Manuela
Blomqvist, Carl
Hillemanns, Peter
Travis, Ruth C.
Keywords: Càncer
Etiologia
Cancer
Etiology
Issue Date: 25-Jan-2019
Publisher: Nature Publishing Group
Abstract: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-08054-4
It is part of: Nature Communications, 2019, vol. 10, p. 431
URI: http://hdl.handle.net/2445/171263
Related resource: https://doi.org/10.1038/s41467-018-08054-4
ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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