Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/171263
Title: Shared heritability and functional enrichment across six solid cancers
Author: Jiang, Xia
Finucane, Hilary K.
Schumacher, Fredrick R.
Schmit, Stephanie L.
Tyrer, Jonathan P.
Han, Younghun
Michailidou, Kyriaki
Lesseur, Corina
Kuchenbaecker, Karoline B.
Dennis, Joe
Conti, David V.
van Rensburg, Elizabeth J.
Riggan, Marjorie J.
Caligo, Maria A.
Weinberg, Clarice R.
Huntsman, David G.
Brauch, Hiltrud
Stone, Jennifer
Haiman, Christopher A.
Christiani, David C.
Claessens, Frank
Landi, Maria Teresa
García-Sáenz, José A.
Ulrich, Cornelia M.
Idos, Gregory
Lindström, Sara
Nussbaum, Robert L.
Tajara, Eloiza H.
Lam, Stephan
Wang, Qin
Kristensen, Vessela N.
Marchand, Loic Le
Nevanlinna, Heli
Weitzel, Jeffrey N.
Franceschi, Silvia
Brunet, Joan
Milne, Roger L.
Hamilton, Robert J.
Kühl, Tabea
Muir, Kenneth
West, Catharine M. L.
Lesse, Davor
Kjaer, Susanne K.
Bickeböller, Heike
Mucci, Lorelei
Jakubowska, Anna
Nikitina-Zake, Liene
Wu, Anna H.
Risch, Angela
Maier, Christiane
Khaw, Kay-Tee
Southey, Melissa C.
Townsend, Paul A.
Thomas, Duncan
Vachon, Celine M.
Eccles, Diana M.
Kote-Jarai, Zsofia
Houlston, Richard
Fasching, Peter A.
Kim, Jeri
Prokofyeva, Darya
Giles, Graham G.
Karlan, Beth Y.
Antoniou, Antonis C.
Kiemeney, Lambertus A.
Bogdanova, Natalia V.
Guénel, Pascal
Batra, Jyotsna
Lindblom, Annika
Amos, Christopher I.
Leslie, Goska
Thomassen, Mads
Al Olama, Ali Amin
Pring, Miranda
Benitez, Javier
Cancel-Tassin, Géraldine
Woods, Michael
Nathanson, Katherine L.
Teixeira, Manuel R.
Saloustros, Emmanouil
Newcomb, Polly A.
Cunningham, Julie M.
John, Esther M.
Couch, Fergus J.
Bolla, Manjeet K.
Goodman, Gary
Evans, D. Gareth
Kaneva, Radka
Offit, Kenneth
Wu, Xifeng
Newcomb, Lisa F.
Stevens, Victoria L.
Singer, Christian F.
Lane, Jacqueline M.
Lenz, Heinz-Josef
Phelan, Catherine M.
Edlund, Christopher K.
Pharoah, Paul D. P.
Gayther, Simon A.
Slattery, Martha L.
Pashayan, Nora
Tung, Nadine
Taylor, Jack A.
Peters, Ulrike
Peters, Wilbert H. M.
Chen, Chu
Bjørge, Line
Hillemanns, Peter
Fostira, Florentia
Shen, Hongbing
Carvalho, André L.
Gronberg, Henrik
Hoffmeister, Michael
Weissler, Mark C.
Haugen, Aage
Simard, Jacques
Loupakis, Fotios
Huyghe, Jeroen R.
Brennan, Paul
Tworoger, Shelley S.
Pasaniuc, Bogdan
Torres, Diana
Schabath, Matthew B.
Andrulis, Irene L.
Kogevinas, Manolis
Benlloch, Sara
Ruyck, Kim De
Olsson, Håkan
Arun, Banu K.
Aronson, Kristan J.
Ingles, Sue Ann
Hsu, Li
Rosenstein, Barry S.
Claes, Kathleen B. M.
Nordestgaard, Børge G.
Cadoni, Gabriella
Diez, Orland
Ferris, Robert L.
Stefansson, Kari
Cannon-Albright, Lisa A.
McGuffog, Lesley
Mannermaa, Arto
Goldberg, Mark S.
Greene, Mark H.
Maehle, Lovise
Yannoukakos, Drakoulis
Garber, Judy
Webb, Penelope M.
Pejovic, Tanja
Toland, Amanda E.
Dörk, Thilo
Whittemore, Alice S.
Hung, Rayjean J.
García-Closas, Montserrat
Li, Li
Friedman, Eitan
Wolk, Alicja
Olopade, Olufunmilayo I.
Risch, Harvey A.
Hamdy, Freddie C.
Tangen, Catherine M.
Middha, Pooja
Terry, Mary Beth
Stanford, Janet L.
Kraft, Peter
Montagna, Marco
Brenton, James D.
Roobol, Monique J.
Hampe, Jochen
Lubiński, Jan
Brenner, Hermann
Neal, David E.
Pandha, Hardev
Sorensen, Karina Dalsgaard
Caldés, Trinidad
Boccia, Stefania
Stintzing, Sebastian
Weinstein, Stephanie
Chan, Andrew T.
Eeles, Rosalind A.
Ellberg, Carolina
Chanock, Stephen J.
Rossing, Mary Anne
Teare, M. Dawn
James, Paul
Berndt, Sonja I.
Campbell, Ian
Fortner, Renée T.
Lee, Eunjung
Chang-Claude, Jenny
May, Taymaa
Gronwald, Jacek
Price, Alkes L.
Casey, Graham
Koutros, Stella
Duell, Eric J.
Chenevix-Trench, Georgia
Neuhausen, Susan L.
Hong, Yun-Chul
Parsons, Michael T.
Margolin, Sara
Schleutker, Johanna
Park, Jong Y.
Knight, Julia A.
Cruz Correa, Marcia
Wiklund, Fredrik
Bandera, Elisa V.
Siegel, Erin M.
Le, Nhu D.
Donovan, Jenny L.
Aldrich, Melinda C.
Velez Edwards, Digna R.
Easton, Douglas F.
Berchuck, Andrew
Devilee, Peter
Heitz, Florian
Hopper, John L.
Hunter, David J.
Albanes, Jeroen R.
Woll, Penella
Liloglou, Triantafillos
Phipps, Amanda I.
Cybulski, Cezary
Li, Christopher I.
Lazarus, Philip
Sawyer, Elinor J.
Meindl, Alfons
Goode, Ellen L.
Barkardottir, Rosa B.
Bien, Stephanie A.
Brunnström, Hans
Goldgar, David E.
Fletcher, Olivia
Moysich, Kirsten B.
Høgdall, Estrid
Gallinger, Steven J.
Elías Aguado-Barrera, Miguel
Imyanitov, Evgeny N.
Clements, Judith
MacInnis, Robert J.
Daly, Mary B.
Anton-Culver, Hoda
Winqvist, Robert
Diergaarde, Brenda
Collée, J. Margriet
Usmani, Nawaid
deFazio, Anna
Czene, Kamila
Ganz, Patricia A.
Campa, Daniele
Ziogas, Argyrios
Plaseska-Karanfilska, Dijana
Gago-Dominguez, Manuela
Blomqvist, Carl
Travis, Ruth C.
Goodman, Marc T.
Kelemen, Linda E.
Van Nieuwenhuysen, Els
Schmidt, Marjanka K.
Figueiredo, Jane C.
Zorn, Kristin K.
Arnold, Susanne M.
Radice, Paolo
Wichmann, H-Erich
Gaudet, Mia M.
Burwinkel, Barbara
Thibodeau, Stephen N.
Saxena, Richa
Hulick, Peter J.
White, Emily
Butzow, Ralf
Beckmann, Matthias W.
Sundfeldt, Karin
Lester, Jenny
Dwek, Miriam
Grankvist, Kjell
Setiawan, V. Wendy
Brook, Mark N.
Rennert, Hedy S.
Lindo, Noralane M.
Sandler, Dale P.
Levine, Douglas A.
Sutphen, Rebecca
Isaacs, Claudine
Zheng, Wei
Campbell, Peter T.
Olshan, Andrew F.
Modugno, Francesmary
Ramu, Susan J.
Cox, Angela
Lambrechts, Diether
Antonenkova, Natalia N.
Andrew, Angeline S.
Johansson, Mikael
Johansson, Mattias
Herrero, Rolando
Håkansson, Niclas
Lejbkowicz, Flavio
Moreno Aguado, Víctor
Gruber, Stephen B.
Sieh, Weiva
Joshi, Amit D.
Olah, Edith
Zienolddiny, Shanbeh
Vega, Ana
Hall, Per
Rennert, Gad
Dunning, Alison M.
Osorio, Ana
Spurdle, Amanda B.
Buchanan, Daniel D.
Hamann, Ute
Caporaso, Neil E.
Penney, Kathryn L.
Jenkins, Mattias
Tardón, Adonina
Kupryjanczyk, Jolanta
Kibel, Adam S.
Terry, Kathryn L.
Ness, Andrew R.
Liu, Geoffrey
Barnes, Daniel R.
Miller, Austin
Tischkowitz, Marc
McKay, James
Raskin, Leon
Bojesen, Stig E.
Nielsen, Finn Cilius
Swerdlow, Anthony J.
Mulligan, Anna Marie
Godwin, Andrew K.
Lacko, Martin
Khusnutdinova, Elza
Keywords: Càncer
Etiologia
Cancer
Etiology
Issue Date: 25-Jan-2019
Publisher: Nature Publishing Group
Abstract: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-08054-4
It is part of: Nature Communications, 2019, vol. 10, p. 431
URI: http://hdl.handle.net/2445/171263
Related resource: https://doi.org/10.1038/s41467-018-08054-4
ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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