Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/171263
Title: Shared heritability and functional enrichment across six solid cancers
Author: Jiang, Xia
Finucane, Hilary K.
Schumacher, Fredrick R.
Schmit, Stephanie L.
Tyrer, Jonathan P.
Han, Younghun
Michailidou, Kyriaki
Lesseur, Corina
Kuchenbaecker, Karoline B.
Dennis, Joe
Conti, David V.
Rennert, Hedy S.
Edlund, Christopher K.
Benlloch, Sara
Stefansson, Kari
Whittemore, Alice S.
Montagna, Marco
Eeles, Rosalind A.
Price, Alkes L.
Weitzel, Jeffrey N.
May, Taymaa
Bandera, Elisa V.
Liloglou, Triantafillos
Moysich, Kirsten B.
deFazio, Anna
Figueiredo, Jane C.
Woods, Michael
Woll, Penella
Grankvist, Kjell
Cox, Angela
Zienolddiny, Shanbeh
Kupryjanczyk, Jolanta
Mulligan, Anna Marie
García-Sáenz, José A.
Nussbaum, Robert L.
Tajara, Eloiza H.
Lam, Stephan
Kristensen, Vessela N.
Marchand, Loic Le
Franceschi, Silvia
Brunet, Joan
Milne, Roger L.
Hamilton, Robert J.
Kühl, Tabea
Muir, Kenneth
West, Catharine M. L.
Lesse, Davor
Mucci, Lorelei
Nikitina-Zake, Liene
Wu, Anna H.
Risch, Angela
Maier, Christiane
Khaw, Kay-Tee
Southey, Melissa C.
Townsend, Paul A.
Thomas, Duncan
Eccles, Diana M.
Fasching, Peter A.
Kim, Jeri
Prokofyeva, Darya
Giles, Graham G.
Karlan, Beth Y.
Antoniou, Antonis C.
Kiemeney, Lambertus A.
Guénel, Pascal
Batra, Jyotsna
Lindblom, Annika
Thomassen, Mads
Al Olama, Ali Amin
Pring, Miranda
Benitez, Javier
Cancel-Tassin, Géraldine
Nathanson, Katherine L.
Teixeira, Manuel R.
Saloustros, Emmanouil
Newcomb, Polly A.
John, Esther M.
Bolla, Manjeet K.
Goodman, Gary
Evans, D. Gareth
Offit, Kenneth
Wu, Xifeng
Newcomb, Lisa F.
Stevens, Victoria L.
Singer, Christian F.
Lenz, Heinz-Josef
Phelan, Catherine M.
Pharoah, Paul D. P.
Slattery, Martha L.
Pashayan, Nora
Tung, Nadine
Taylor, Jack A.
Peters, Ulrike
Peters, Wilbert H. M.
Bjørge, Line
Hillemanns, Peter
Fostira, Florentia
Gronberg, Henrik
Hoffmeister, Michael
Weissler, Mark C.
Jakubowska, Anna
Chan, Andrew T.
Cruz Correa, Marcia
Hopper, John L.
Barkardottir, Rosa B.
Daly, Mary B.
Blomqvist, Carl
Burwinkel, Barbara
Pasaniuc, Bogdan
Wichmann, H-Erich
Lambrechts, Diether
Olah, Edith
Jenkins, Mattias
Bojesen, Stig E.
Brauch, Hiltrud
Wang, Qin
Kjaer, Susanne K.
Kote-Jarai, Zsofia
Leslie, Goska
Couch, Fergus J.
Carvalho, André L.
Haugen, Aage
Simard, Jacques
Loupakis, Fotios
Brennan, Paul J.
Tworoger, Shelley S.
Torres, Diana
Schabath, Matthew B.
Andrulis, Irene L.
Kogevinas, Manolis
Ruyck, Kim De
Olsson, Håkan
Arun, Banu K.
Ingles, Sue Ann
Rosenstein, Barry S.
Claes, Kathleen B. M.
Nordestgaard, Børge G.
Cadoni, Gabriella
Diez, Orland
Ferris, Robert L.
Cannon-Albright, Lisa
McGuffog, Lesley
Greene, Mark H.
Maehle, Lovise
Yannoukakos, Drakoulis
Garber, Judy
Webb, Penelope M.
Pejovic, Tanja
Toland, Amanda E.
Dörk, Thilo
Hung, Rayjean J.
Friedman, Eitan
Wolk, Alicja
Olopade, Olufunmilayo I.
Risch, Harvey A.
Hamdy, Freddie C.
Tangen, Catherine M.
Middha, Pooja
Terry, Mary Beth
Stanford, Janet L.
Roobol, Monique J.
Hampe, Jochen
Lubiński, Jan
Brenner, Hermann
Neal, David E.
Pandha, Hardev
Sorensen, Karina Dalsgaard
Caldés, Trinidad
Stintzing, Sebastian
Weinstein, Stephanie
Ellberg, Carolina
Chanock, Stephen J.
Rossing, Mary Anne
Teare, M. Dawn
James, Paul
Berndt, Sonja I.
Fortner, Renée T.
Lee, Eunjung
Chang-Claude, Jenny
Gronwald, Jacek
Casey, Graham
Hsu, Li
Gago-Dominguez, Manuela
Setiawan, V. Wendy
Modugno, Francesmary
Moreno Aguado, Víctor
Spurdle, Amanda B.
Liu, Geoffrey
Lacko, Martin
Claessens, Frank
Houlston, Richard
Amos, Christopher I.
Cunningham, Julie M.
Lane, Jacqueline M.
Chen, Chu
Huyghe, Jeroen R.
Aronson, Kristan J.
Mannermaa, Arto
Li, Li
Brenton, James D.
Koutros, Stella
Duell, Eric J.
Chenevix-Trench, Georgia
Hong, Yun-Chul
Parsons, Michael T.
Margolin, Sara
Schleutker, Johanna
Park, Jong Y.
Knight, Julia A.
Wiklund, Fredrik
Siegel, Erin M.
Donovan, Jenny L.
Aldrich, Melinda C.
Velez Edwards, Digna R.
Easton, Douglas F.
Berchuck, Andrew
Devilee, Peter
Heitz, Florian
Hunter, David J.
Albanes, Jeroen R.
Phipps, Amanda I.
Cybulski, Cezary
Li, Christopher I.
Lazarus, Philip
Sawyer, Elinor J.
Meindl, Alfons
Goode, Ellen L.
Bien, Stephanie A.
Goldgar, David E.
Fletcher, Olivia
Høgdall, Estrid
Gallinger, Steven J.
Elías Aguado-Barrera, Miguel
Imyanitov, Evgeny N.
Clements, Judith
MacInnis, Robert J.
Winqvist, Robert
Diergaarde, Brenda
Collée, J. Margriet
Usmani, Nawaid
Czene, Kamila
Ganz, Patricia A.
Campa, Daniele
Ziogas, Argyrios
Plaseska-Karanfilska, Dijana
Travis, Ruth C.
Goodman, Marc T.
Kelemen, Linda E.
Van Nieuwenhuysen, Els
Schmidt, Marjanka K.
Zorn, Kristin K.
Arnold, Susanne M.
Radice, Paolo
Gaudet, Mia M.
Thibodeau, Stephen N.
Landi, Maria Teresa
Nevanlinna, Heli
Bickeböller, Heike
Vachon, Celine M.
Bogdanova, Natalia V.
Kaneva, Radka
Gayther, Simon A.
Shen, Hongbing
Goldberg, Mark S.
García-Closas, Montserrat
Kraft, Peter
Boccia, Stefania
Campbell, Ian
Neuhausen, Susan L.
Le, Nhu D.
Brunnström, Hans
Anton-Culver, Hoda
Saxena, Richa
Hulick, Peter J.
White, Emily
Butzow, Ralf
Beckmann, Matthias W.
Sundfeldt, Karin
Lester, Jenny
Dwek, Miriam
Brook, Mark N.
Lindo, Noralane M.
Sandler, Dale P.
Levine, Douglas A.
Sutphen, Rebecca
Isaacs, Claudine
Zheng, Wei
Campbell, Peter T.
Olshan, Andrew F.
Ramu, Susan J.
Antonenkova, Natalia N.
Andrew, Angeline S.
Johansson, Mikael
Johansson, Mattias
Herrero, Rolando
Håkansson, Niclas
Lejbkowicz, Flavio
Gruber, Stephen B.
Sieh, Weiva
Joshi, Amit D.
Vega, Ana
Hall, Per
Rennert, Gad
Dunning, Alison M.
Osorio, Ana
Buchanan, Daniel D.
Hamann, Ute
Caporaso, Neil
Penney, Kathryn L.
Tardon, Adonina
Kibel, Adam S.
Terry, Kathryn L.
Ness, Andrew R.
Barnes, Daniel R.
Miller, Austin
Tischkowitz, Marc
McKay, James
Raskin, Leon
Nielsen, Finn Cilius
Swerdlow, Anthony J.
Godwin, Andrew K.
Khusnutdinova, Elza
van Rensburg, Elizabeth J.
Riggan, Marjorie J.
Caligo, Maria A.
Weinberg, Clarice R.
Huntsman, David G.
Stone, Jennifer
Haiman, Christopher A.
Christiani, David C.
Ulrich, Cornelia M.
Idos, Gregory
Lindström, Sara
Keywords: Càncer
Etiologia
Cancer
Etiology
Issue Date: 25-Jan-2019
Publisher: Nature Publishing Group
Abstract: Quantifying the genetic correlation between cancers can provide important insights into the mechanisms driving cancer etiology. Using genome-wide association study summary statistics across six cancer types based on a total of 296,215 cases and 301,319 controls of European ancestry, here we estimate the pair-wise genetic correlations between breast, colorectal, head/neck, lung, ovary and prostate cancer, and between cancers and 38 other diseases. We observed statistically significant genetic correlations between lung and head/neck cancer (rg = 0.57, p = 4.6 × 10-8), breast and ovarian cancer (rg = 0.24, p = 7 × 10-5), breast and lung cancer (rg = 0.18, p =1.5 × 10-6) and breast and colorectal cancer (rg = 0.15, p = 1.1 × 10-4). We also found that multiple cancers are genetically correlated with non-cancer traits including smoking, psychiatric diseases and metabolic characteristics. Functional enrichment analysis revealed a significant excess contribution of conserved and regulatory regions to cancer heritability. Our comprehensive analysis of cross-cancer heritability suggests that solid tumors arising across tissues share in part a common germline genetic basis.
Note: Reproducció del document publicat a: https://doi.org/10.1038/s41467-018-08054-4
It is part of: Nature Communications, 2019, vol. 10, p. 431
URI: http://hdl.handle.net/2445/171263
Related resource: https://doi.org/10.1038/s41467-018-08054-4
ISSN: 2041-1723
Appears in Collections:Articles publicats en revistes (ISGlobal)
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)

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