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Title: Barley β-glucan accelerates wound healing by favoring migration versus proliferation of human dermal fibroblasts
Author: Fusté, Noel P.
Guasch, M.
Guillen, P.
Anerillas, C.
Cemeli, T.
Pedraza, N.
Ferrezuelo, F.
Encinas, M.
Moralejo, M.
Garí, Eloi
Keywords: Polisacàrids
Issue Date: 15-Apr-2019
Publisher: Elsevier Science Ltd.
Abstract: β-Glucans are considered candidates for the medication in different human pathologies. In this work, we have purified β-glucan from a selected barley line and tested their effects in primary human dermal fibroblasts. Unexpectedly, we have observed that this compound promoted a short-transitory proliferation arrest at 24 h after its addition on the medium. We have determined that this transitory arrest was dependent on the cell-cycle regulator protein Retinoblastoma. Moreover, dermal fibroblasts increase their migration capacities at 24 h after barley β-glucan addition. Also, we have described that barley β-glucan strongly reduced the ability of fibroblasts to attach and to spread on cell plates. Our data indicates that barley β-glucan signal induces an early response in HDF cells favoring migration versus proliferation. This feature is consistent with our observation that the topical addition of our barley β-glucan in vivo accelerates the wound closure in mouse skin.
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It is part of: Carbohydrate Polymers, 2019, vol. 210, p. 389-398
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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