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Title: Genomic imprinting disorders: lessons on how genome, epigenome and environment interact
Author: Monk, Dave Nicholas
Mackay, Deborah J. G
Eggermann, Thomas
Maher, Eamonn R.
Riccio, Andrea
Keywords: Epigenètica
Issue Date: 1-Apr-2019
Publisher: Nature Publishing Group
Abstract: Genomic imprinting, the monoallelic and parent-of-origin-dependent expression of a subset of genes, is required for normal development, and its disruption leads to human disease. Imprinting defects can involve isolated or multilocus epigenetic changes that may have no evident genetic cause, or imprinting disruption can be traced back to alterations of cis-acting elements or trans-acting factors that control the establishment, maintenance and erasure of germline epigenetic imprints. Recent insights into the dynamics of the epigenome, including the effect of environmental factors, suggest that the developmental outcomes and heritability of imprinting disorders are influenced by interactions between the genome, the epigenome and the environment in germ cells and early embryos.
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It is part of: Nature Reviews Genetics, 2019-04-01, Vol. 20, num. 4, P. 235-248
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Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

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