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Title: | Special issue: G protein-coupled adenosine receptors: molecular aspects and beyond |
Author: | Ciruela Alférez, Francisco |
Keywords: | Adenosina Proteïnes G Molècules Adenosine G Proteins Molecules |
Issue Date: | 15-Mar-2020 |
Publisher: | MDPI |
Abstract: | Adenosine is a purine nucleoside present in all human cells where it plays many different physiological roles: From being a building block for nucleic acids to a key constituent of the biological energy currency ATP. Indeed, more than 90 years ago, Drury and Szent-Györgyi reported that adenosine produces profound hypotension and bradycardia, and until the present time, the list of physiological effects of adenosine has expanded considerably. In addition, adenosine is a well-known neuromodulator in the brain and has effects on other tissues, thus exerting its physiological actions through four different subtypes of G protein-coupled adenosine receptors (i.e., A1R, A2AR, A2BR and A3R) which, as expected, are expressed in a large variety of cells throughout the body. Consequently, ARs are potential therapeutic targets in a variety of pathophysiological conditions, including cancer, cardiovascular diseases, neurological disorders, and inflammatory and autoimmune diseases. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/ijms21061997 |
It is part of: | International Journal of Molecular Sciences, 2020, vol. 21, num. 6, p. 1997 |
URI: | http://hdl.handle.net/2445/172685 |
Related resource: | https://doi.org/10.3390/ijms21061997 |
ISSN: | 1661-6596 |
Appears in Collections: | Articles publicats en revistes (Patologia i Terapèutica Experimental) Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) |
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