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Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/172791
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dc.contributor.authorUrrea Zazurca, Laura-
dc.contributor.authorSegura Feliu, Miriam-
dc.contributor.authorMasuda-Suzukake, Masami-
dc.contributor.authorHervera Abad, Arnau-
dc.contributor.authorPedraz López, Lucas-
dc.contributor.authorGarcía Aznar, José Manuel-
dc.contributor.authorVila, Miquel-
dc.contributor.authorSamitier i Martí, Josep-
dc.contributor.authorTorrents Serra, Eduard-
dc.contributor.authorFerrer, Isidro (Ferrer Abizanda)-
dc.contributor.authorGavín Marín, Rosalina-
dc.contributor.authorHagesawa, Masato-
dc.contributor.authorRío Fernández, José Antonio del-
dc.date.accessioned2020-12-15T18:21:14Z-
dc.date.available2020-12-15T18:21:14Z-
dc.date.issued2018-03-01-
dc.identifier.urihttp://hdl.handle.net/2445/172791-
dc.description.abstractThe cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of beta-amyloid. Their interaction is mandatory for neurotoxic effects of beta-amyloid oligomers. In this study, we aimed to explore whether the cellular prion protein participates in the spreading of alpha-synuclein. Results demonstrate that Prnp expression is not mandatory for alpha-synuclein spreading. However, although the pathological spreading of alpha-synuclein can take place in the absence of Prnp, alpha-synuclein expanded faster in PrPC-overexpressing mice. In addition, alpha-synuclein binds strongly on PrPC-expressing cells, suggesting a role in modulating the effect of alpha-synuclein fibrils.-
dc.format.mimetypeapplication/pdf-
dc.language.isoeng-
dc.publisherSpringer-
dc.relation.isformatofReproducció del document publicat a: https://doi.org/10.1007/s12035-017-0451-4-
dc.relation.ispartofMolecular Neurobiology, 2018, vol. 55, num. 3, p. 1847-1860-
dc.relation.urihttps://doi.org/10.1007/s12035-017-0451-4-
dc.rightscc by (c) Urrea Zazurca et al., 2018-
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/es/-
dc.sourceArticles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)-
dc.subject.classificationAlfa-sinucleïna-
dc.subject.classificationPrions-
dc.subject.otherAlpha-synuclein-
dc.subject.otherPrions-
dc.titleInvolvement of Cellular Prion Protein in alpha-Synuclein Transport in Neurons-
dc.typeinfo:eu-repo/semantics/article-
dc.typeinfo:eu-repo/semantics/publishedVersion-
dc.date.updated2020-12-04T12:33:49Z-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/228685/EU//BOND-
dc.relation.projectIDinfo:eu-repo/grantAgreement/EC/FP7/278486/EU//DEVELAGE-
dc.rights.accessRightsinfo:eu-repo/semantics/openAccess-
dc.identifier.pmid28229331-
Appears in Collections:Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))
Articles publicats en revistes (Institut de Neurociències (UBNeuro))
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
Articles publicats en revistes (Enginyeria Electrònica i Biomèdica)
Publicacions de projectes de recerca finançats per la UE

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