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http://hdl.handle.net/2445/174260
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DC Field | Value | Language |
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dc.contributor.author | Griguolo, Gaia | - |
dc.contributor.author | Brasó Maristany, Fara | - |
dc.contributor.author | Gonzalez Farré, Blanca | - |
dc.contributor.author | Pascual, Tomás | - |
dc.contributor.author | Chic, Núria | - |
dc.contributor.author | Saurí, Tamara | - |
dc.contributor.author | Kates, Ronald | - |
dc.contributor.author | Gluz, Oleg | - |
dc.contributor.author | Martínez, Débora | - |
dc.contributor.author | Paré, Laia | - |
dc.contributor.author | Tsvetkova, Vassilena | - |
dc.contributor.author | Pesantez, David | - |
dc.contributor.author | Vidal Losada, Maria Jesús | - |
dc.contributor.author | Adamo, Barbara | - |
dc.contributor.author | Muñoz Mateu, Montserrat | - |
dc.contributor.author | Galván, Patricia | - |
dc.contributor.author | Barberá, Laura | - |
dc.contributor.author | Cuatrecasas Freixas, Miriam | - |
dc.contributor.author | Christgen, Mathias | - |
dc.contributor.author | Kreipe, Hans | - |
dc.contributor.author | Monge Escartín, Inés | - |
dc.contributor.author | Villagrasa, Patricia | - |
dc.contributor.author | Soy Muner, Dolors | - |
dc.contributor.author | Giarratano, Tommaso | - |
dc.contributor.author | Dieci, Maria Vittoria | - |
dc.contributor.author | Conte, Pierfranco | - |
dc.contributor.author | Harbeck, Nadia | - |
dc.contributor.author | Guarneri, Valentina | - |
dc.contributor.author | Prat Aparicio, Aleix | - |
dc.date.accessioned | 2021-02-24T16:59:37Z | - |
dc.date.available | 2021-02-24T16:59:37Z | - |
dc.date.issued | 2020-07-14 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | http://hdl.handle.net/2445/174260 | - |
dc.description.abstract | Trastuzumab emtansine (T-DM1) is approved for the treatment of human epidermal growth factor receptor 2 (HER2)-positive (HER2+) metastatic breast cancer (BC) and for residual disease after neoadjuvant therapy; however, not all patients benefit. Here, we hypothesized that the heterogeneity in the response seen in patients is partly explained by the levels of human epidermal growth factor receptor 2 gene (ERBB2) mRNA.We analyzed ERBB2 expression using a clinically applicable assay in formalin-fixed para n-embedded (FFPE) tumors (primary or metastatic) from a retrospective series of 77 patients with advanced HER2+ BC treated with T-DM1. The association of ERBB2 levels and response was further validated in 161 baseline tumors from the West German Study (WGS) Group ADAPT phase II trial exploring neoadjuvant T-DM1 and 9 in vitro BC cell lines. Finally, | - |
dc.format.extent | 15 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | MDPI | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.3390/cancers12071902 | - |
dc.relation.ispartof | Cancers, 2020, vol. 12(7), num. 1902 | - |
dc.relation.uri | https://doi.org/10.3390/cancers12071902 | - |
dc.rights | cc-by (c) Griguolo, Gaia et al., 2020 | - |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/es | - |
dc.source | Articles publicats en revistes (Medicina) | - |
dc.subject.classification | Càncer de mama | - |
dc.subject.classification | Receptors d'hormones | - |
dc.subject.other | Breast cancer | - |
dc.subject.other | Hormone receptors | - |
dc.title | ERBB2mRNA expression and response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-positive breast cancer | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 704764 | - |
dc.date.updated | 2021-02-24T16:59:37Z | - |
dc.relation.projectID | info:eu-repo/grantAgreement/EC/H2020/847912/EU//RESCUER | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
dc.identifier.pmid | 32674482 | - |
Appears in Collections: | Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer) Publicacions de projectes de recerca finançats per la UE Articles publicats en revistes (Medicina) |
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File | Description | Size | Format | |
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704764.pdf | 3.27 MB | Adobe PDF | View/Open |
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