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dc.contributor.authorGriguolo, Gaia-
dc.contributor.authorBrasó Maristany, Fara-
dc.contributor.authorGonzalez Farré, Blanca-
dc.contributor.authorPascual, Tomás-
dc.contributor.authorChic, Núria-
dc.contributor.authorSaurí, Tamara-
dc.contributor.authorKates, Ronald-
dc.contributor.authorGluz, Oleg-
dc.contributor.authorMartínez, Débora-
dc.contributor.authorParé, Laia-
dc.contributor.authorTsvetkova, Vassilena-
dc.contributor.authorPesantez, David-
dc.contributor.authorVidal Losada, Maria Jesús-
dc.contributor.authorAdamo, Barbara-
dc.contributor.authorMuñoz Mateu, Montserrat-
dc.contributor.authorGalván, Patricia-
dc.contributor.authorBarberá, Laura-
dc.contributor.authorCuatrecasas Freixas, Miriam-
dc.contributor.authorChristgen, Mathias-
dc.contributor.authorKreipe, Hans-
dc.contributor.authorMonge Escartín, Inés-
dc.contributor.authorVillagrasa, Patricia-
dc.contributor.authorSoy Muner, Dolors-
dc.contributor.authorGiarratano, Tommaso-
dc.contributor.authorDieci, Maria Vittoria-
dc.contributor.authorConte, Pierfranco-
dc.contributor.authorHarbeck, Nadia-
dc.contributor.authorGuarneri, Valentina-
dc.contributor.authorPrat Aparicio, Aleix-
dc.description.abstractTrastuzumab emtansine (T-DM1) is approved for the treatment of human epidermal growth factor receptor 2 (HER2)-positive (HER2+) metastatic breast cancer (BC) and for residual disease after neoadjuvant therapy; however, not all patients benefit. Here, we hypothesized that the heterogeneity in the response seen in patients is partly explained by the levels of human epidermal growth factor receptor 2 gene (ERBB2) mRNA.We analyzed ERBB2 expression using a clinically applicable assay in formalin-fixed para n-embedded (FFPE) tumors (primary or metastatic) from a retrospective series of 77 patients with advanced HER2+ BC treated with T-DM1. The association of ERBB2 levels and response was further validated in 161 baseline tumors from the West German Study (WGS) Group ADAPT phase II trial exploring neoadjuvant T-DM1 and 9 in vitro BC cell lines. Finally,-
dc.format.extent15 p.-
dc.relation.isformatofReproducció del document publicat a:
dc.relation.ispartofCancers, 2020, vol. 12(7), num. 1902-
dc.rightscc-by (c) Griguolo, Gaia et al., 2020-
dc.subject.classificationCàncer de mama-
dc.subject.classificationReceptors d'hormones-
dc.subject.otherBreast cancer-
dc.subject.otherHormone receptors-
dc.titleERBB2mRNA expression and response to Ado-Trastuzumab Emtansine (T-DM1) in HER2-positive breast cancer-
Appears in Collections:Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)
Articles publicats en revistes (Medicina)

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