Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/174530
Title: Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
Author: Munn Chernoff, Melissa A.
Johnson, Emma C.
Chou, Yi Ling
Coleman, Jonathan R. I.
Thornton, Laura M.
Walters, Raymond K.
Yilmaz, Zeynep
Baker, Jessica H.
Hübel, Christopher
Gordon, Scott
Medland, Sarah E.
Meyers, Jacquelyn L.
Nacmias, Benedeta
Kuperman, Samuel
Van Elburg, Annemarie A.
O'Toole, Julie K.
Karwautz, Andreas
Heath, Andrew C.
Kaye, Walter H.
Slof-Op't Landt, Margarita C. T.
Larsen, Janne T.
Hanscombe, Ken B.
Van Furth, Eric F.
Ryu, Euijung
Maes, Hermine H.
Lahti Pulkkinen, Marius
Estivill, Xavier, 1955-
Saccone, Nancy L.
Lissowska, Jolanta
Degenhardt, Louisa
Ritschel, Franziska
Brown, Sandra A.
Adkins, Amy E.
Johnson, Craig
Vanyukov, Michael M.
Ligthart, Lannie
Giuranna, Johanna
Janout, Vladimir
Heilmann Heimbach, Stefanie
Kiefer, Falk
Imgart, Hartmut
Edenberg, Howard J.
Walton, Esther
Micali, Nadia
Müller Myhsok, Bertram
Hellard, Stephanie Le
Keski Rahkonen, Anna
Sullivan, Patrick F.
Dikeos, Dimitris
Hartmann, Annette M.
Webb, Bradley T.
Hudson, James I.
Diazgranados, Nancy
Hebebrand, Johannes
Gratacos Mayora, Monica
Andreassen, Ole A.
Dedoussis, George
Krauter, Kenneth
Costello, E. Jane
Guillaume, Sébastien
Navratilova, Marie
Leppä, Virpi M.
Kennedy, James L.
Tsitsika, Artemis
Crawford, Steve
Treutlein, Jens
Świątkowska, Beata
Zeggini, Eleftheria
Treasure, Janet
Monteleone, Palmiero
Vrieze, Scott
Nöthen, Markus M.
Bergen, Andrew W.
Räikkönen, Katri
Ricca, Valdo
Marshall, Christian R.
Stallings, Michael C.
Chen, Danfeng
Hatzikotoulas, Konstantinos
Gaspar, Héléna A.
Zwaan, Martina de
Lilenfeld, Lisa
Scherer, Stephen W.
Dina, Christian
Scherbaum, Norbert
Schosser, Alexandra
Goldman, David
Kaplan, Allan S.
Tortorella, Alfonso
DeSocio, Janiece E.
Rietschel, Marcella
Pearson, John F.
Wit, Harriet de
Esko, Tõnu
Padyukov, Leonid
Guo, Yiran
Rice, John P.
Pantel, Jacques
Helder, Sietske G.
Schuckit, Marc A.
Crow, Scott
Degortes, Daniela
Dmitrzak Weglarz, Monika
Rotondo, Alessandro
Schmidt, Ulrike
Batzler, Anthony
Johnson, Eric O.
Penninx, Brenda W. J. H.
Rybakowski, Filip
Shen, Pei-Hong
Docampo, Elisa
Choi, Doo-Sup
Widen, Elisabeth
Slopien, Agnieszka
Aliev, Fazil
Copeland, William E.
Bigdeli, Tim B.
Jiménez-Murcia, Susana
Sorbi, Sandro
Whitfield, John B.
Edwards, Alexis C.
Wall, Tamara L.
Courtet, Philippe
Konte, Bettina
Goate, Alison M.
Maj, Mario
Palmer, Abraham A.
Maier, Wolfgang
Frye, Mark A.
Franklin, Christopher S.
Bulik, Cynthia M.
Inoko, Hidetoshi
Sherva, Richard
Montgomery, Grant W.
Egberts, Karim
Kaprio, Jaakko
Bertelsen, Sarah
Bucholz, Kathleen K.
Metspalu, Andres
Wodarz, Norbert
Kennedy, Martin A
Levitan, Robert D.
Ripke, Stephan
Murray, Alison D.
Norring, Claes
Buehren, Katharina
Gäbel, Wolfgang
Woodside, D. Blake
Neale, Benjamin M.
Ando, Tetsuya
Grucza, Richard A.
Reichborn Kjennerud, Tez
Streit, Fabian
Julià, Antonio
Lynskey, Michael T.
Gorwood, Philip
Halmi, Katherine A.
Tenconi, Elena
Li-Shiun , Chen
Männistö, Satu
Papezova, Hana
McQueen, Matthew B.
Nurnberger, John I
Schwandt, Melanie
Kaminská, Deborah
Bacanu, Silviu Alin
Landén, Mikael
Mattingsdal, Morten
Domingue, Benjamin W.
Rose, Richard J.
Bryois, Julien
Farrer, Lindsay A.
Huckins, Laura M.
Kranzler, Henry R.
Watson, Hunna J.
Dick, Danielle M.
McDevitt, Sara
Hartz, Sarah M.
Madden, Pamela A.F .
Nelson, Elliot C.
Tachmazidou, Ioanna
Herzog, Wolfgang
Hesselbrock, Victor
Danner, Unna N.
Iacono, William G.
Hodgkinson, Colin
Horwood, L. John
Ehrlich, Stefan
Tziouvas, Konstantinos
Wagner, Gudrun
Davis, Oliver S. P.
Karhunen, Leila
Sanchez Roige, Sandra
McGue, Matt
Salvatore, Jessica E.
Parker, Richard
Grove, Jakob
Hoffmann, Per
Docherty, Anna R.
Cassina, Matteo
Adan, Robert A. H.
Eriksson, Johan G.
Slagboom, P. Eline
Loukola, Anu
Birgegård, Andreas
Bierut, Laura J.
Rujescu, Dan
Hewitt, John K.
Kendler, Kenneth S.
Zipfel, Stephan
Agrawal, Arpana
Roberts, Marion
Pinto, Dalila
Peterson, Roseann E.
Reynolds, Maureen D.
Breen, Gerome
Gillespie, Nathan A.
Fox, Louis
Escaramís, Geòrgia
Forstner, Andreas J.
Porjesz, Bernice
Berrettini, Wade H.
Boomsma, Dorret I.
Koller, Gabriele
Frank, Josef
Magistretti, Pierre J.
Polimanti, Renato
Boden, Joseph M.
Zill, Peter
Mitchell, James
Scherag, André
Mbarek, Hamdi
Herpertz-Dahlmann, Beate
Dahmen, Norbert
Silberg, Judy
Luykx, Jurjen
McClintick, Jeanette N.
Slachtova, Lenka
Gonidakis, Fragiskos
Santonastaso, Paolo
Pedersen, Nancy L.
Mattheisen, Manuel
Hack, Laura M.
Rabionet Janssen, Raquel
Mullan Harris, Kathleen
Tyszkiewicz Nwafor, Marta
Hottenga, Jouke Jan
Palotie, Aarno
McGuffin, Peter
Giusti Rodríguez, Paola
Tarter, Ralph E.
Mannik, Katrin
Ophoff, Roel A.
Karpyak, Victor M.
Dong, Li
Olsen, Catherine M.
Ising, Marcus
Marsal, Sara
Soyka, Michael
Lahti, Jari
Keyes, Margaret
Herms, Stefan
Witt, Stephanie H.
Strohmaier, Jana
Kiezebrink, Kirsty
Boardman, Jason D.
Knudsen, Gun Peggy S.
Lind, Penelope A.
Dongbing, Lai
Wade, Tracey D.
Hakonarson, Hakon
Ripatti, Samuli
Ramoz, Nicolas
Meulenbelt, Ingrid
Kalsi, Gursharan
La Via, Maria C.
Zerwas, Stephanie
Strober, Michael
Giegling, Ina
Palviainen, Teemu
Magnusson, Patrik K. E.
Szatkiewicz, Jin P.
Brandt, Harry
Kim, Youl R.
Preuss, Ulrich
Boraska Perica, Vesna
Hayward, Caroline
Gelernter, Joel
Martin, Nicholas G.
Foo, Jerome C.
Zhou, Hang
Wetherill, Leah
Cichon, Sven
Clementi, Maurizio
Duncan, Laramie E.
Alfredsson, Lars
Schork, Nicholas J.
Foroud, Tatiana M.
Danae Lin, Bochao
Kas, Martien J.H.
Ntalla, Ioanna
Kramer, John
Fischer, Krista
Gallinger, Steven
Ridinger, Monika
Jordan, Jennifer
Riley, Brien P.
Biernacka, Joanna M.
Hinney, Anke
Wills, Amanda G.
McIntosh, Andrew M.
Föcker, Manuel
Hauser, Joanna
Clarke, Toni-Kim
Hancock, Dana B.
Hopfer, Christian J.
Schosser, Jochen
Degenhardt, Franziska
Zhao, Hongyu
Burghardt, Roland
Mann, Karl
Thomas, Nathaniel
Werge, Thomas
Cone, Roger D.
Milaneschi, Yuri
Raevuori, Anu
Lichtenstein, Paul
Yao, Shuyang
Maher, Brion S.
Foretova, Lenka
Boni, Claudette
Wedow, Robbee
MacKillop, James
Fichter, Manfred M.
Crowley, James J.
Culverhouse, Robert C.
Forzan, Monica
Monteleone, Alessio Maria
Adkins, Daniel E.
Klump, Kelly L.
Lucae, Susanne
Boehm, Ilka
Henders, Anjali K.
Wang, Jen-Chyong
Tozzi, Federica
Bo Mortensen, Preben
Mitchell, Karen
Keywords: Trastorns de la conducta alimentària
Genètica
Factors de risc en les malalties
Fenotip
Consum d'alcohol
Abús de substàncies
Eating disorders
Genetics
Risk factors in diseases
Phenotype
Drinking of alcoholic beverages
Substance abuse
Issue Date: 16-Feb-2020
Publisher: Wiley
Abstract: Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.
Note: Versió postprint del document publicat a: https://doi.org/10.1111/adb.12880
It is part of: Addiction Biology, 2020, vol. 26(1), num. e12880
URI: http://hdl.handle.net/2445/174530
Related resource: https://doi.org/10.1111/adb.12880
ISSN: 1355-6215
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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