Please use this identifier to cite or link to this item: http://hdl.handle.net/2445/174530
Title: Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies
Author: Munn-Chernoff, Melissa A.
Johnson, Emma C.
Chou, Yi Ling
Coleman, Jonathan R. I.
Thornton, Laura M.
Walters, Raymond K.
Yilmaz, Zeynep
Baker, Jessica H.
Hübel, Christopher
Gordon, Scott
Medland, Sarah E.
Marshall, Christian R.
Stallings, Michael C.
Chen, Danfeng
Hatzikotoulas, Konstantinos
Gaspar, Héléna A.
Salvatore, Jessica E.
Zwaan, Martina de
Lilenfeld, Lisa
Scherer, Stephen W.
Witt, Stephanie H.
Werge, Thomas
Edwards, Alexis C.
Dina, Christian
Scherbaum, Norbert
Schosser, Alexandra
Goldman, David
Kaplan, Allan S.
Tortorella, Alfonso
Parker, Richard
DeSocio, Janiece E.
Rietschel, Marcella
Cone, Roger D.
Rybakowski, Filip
Pearson, John F.
Wit, Harriet de
Wall, Tamara L.
Esko, Tõnu
Padyukov, Leonid
Guo, Yiran
Rice, John P.
Pantel, Jacques
Grove, Jakob
Milaneschi, Yuri
Helder, Sietske G.
Herzog, Wolfgang
Schuckit, Marc A.
Courtet, Philippe
Konte, Bettina
Goate, Alison M.
Maj, Mario
Palmer, Abraham A.
Maier, Wolfgang
Frye, Mark A.
Raevuori, Anu
Franklin, Christopher S.
Hoffmann, Per
Strohmaier, Jana
Kuperman, Samuel
Bulik, Cynthia M.
Inoko, Hidetoshi
Sherva, Richard
Montgomery, Grant W.
Egberts, Karim
Kaprio, Jaakko
Lichtenstein, Paul
Bertelsen, Sarah
Bucholz, Kathleen K.
Metspalu, Andres
Kiezebrink, Kirsty
Docherty, Anna R.
Wodarz, Norbert
Van Elburg, Annemarie A.
Kennedy, Martin A
Levitan, Robert D.
Ripke, Stephan
Aliev, Fazil
Murray, Alison D.
Norring, Claes
Buehren, Katharina
Gäbel, Wolfgang
Boardman, Jason D.
Woodside, D. Blake
Cassina, Matteo
Neale, Benjamin M.
Ando, Tetsuya
O'Toole, Julie K.
Yao, Shuyang
Grucza, Richard A.
Reichborn Kjennerud, Tez
Streit, Fabian
Julià, Antonio
Lynskey, Michael T.
Knudsen, Gun Peggy S.
Gorwood, Philip
Halmi, Katherine A.
Degortes, Daniela
Tenconi, Elena
Maher, Brion S.
Li-Shiun , Chen
Männistö, Satu
Karwautz, Andreas
Papezova, Hana
McQueen, Matthew B.
Nurnberger, John I
Lind, Penelope A.
Schwandt, Melanie
Kaminská, Deborah
Bacanu, Silviu Alin
Foretova, Lenka
Larsen, Janne T.
Landén, Mikael
Mattingsdal, Morten
Domingue, Benjamin W.
Rose, Richard J.
Heath, Andrew C.
Bryois, Julien
Dongbing, Lai
Farrer, Lindsay A.
Huckins, Laura M.
Wagner, Gudrun
Kranzler, Henry R.
Watson, Hunna J.
Adan, Roger A. H.
Dick, Danielle M.
McDevitt, Sara
Hartz, Sarah M.
Madden, Pamela A.F .
Nelson, Elliot C.
Wade, Tracey D.
Kaye, Walter H.
Olsen, Catherine M.
Tachmazidou, Ioanna
Eriksson, Johan G.
Slagboom, P. Eline
Loukola, Anu
Birgegård, Andreas
Bierut, Laura J.
Rujescu, Dan
Hewitt, John K.
Kendler, Kenneth S.
Saccone, Nancy L.
Johnson, Craig
Dmitrzak Weglarz, Monika
Zipfel, Stephan
Hanscombe, Ken B.
Agrawal, Arpana
Roberts, Marion
Pinto, Dalila
Peterson, Roseann E.
Reynolds, Maureen D.
Breen, Gerome
Gillespie, Nathan A.
Boni, Claudette
Hakonarson, Hakon
Fox, Louis
Rotondo, Alessandro
Escaramís, Geòrgia
Forstner, Andreas J.
Van Furth, Eric F.
Porjesz, Bernice
Berrettini, Wade H.
Boomsma, Dorret I.
Koller, Gabriele
Wedow, Robbee
Frank, Josef
Ripatti, Samuli
Magistretti, Pierre J.
Polimanti, Renato
Schmidt, Ulrike
Boden, Joseph M.
Zill, Peter
Mitchell, James
Ryu, Euijung
Scherag, André
MacKillop, James
Mbarek, Hamdi
Herpertz-Dahlmann, Beate
Hesselbrock, Victor
Dahmen, Norbert
Silberg, Judy
Luykx, Jurjen
Batzler, Anthony
McClintick, Jeanette N.
Slachtova, Lenka
Gonidakis, Fragiskos
Fichter, Manfred M.
Santonastaso, Paolo
Maes, Hermine H.
Pedersen, Nancy L.
Shen, Pei-Hong
Mattheisen, Manuel
Hack, Laura M.
Rabionet Janssen, Raquel
Mullan Harris, Kathleen
Johnson, Eric O.
Tyszkiewicz-Nwafor, Marta
Crowley, James J.
Hottenga, Jouke Jan
Palotie, Aarno
McGuffin, Peter
Giusti Rodríguez, Paola
Ramoz, Nicolas
Lahti Pulkkinen, Marius
Tarter, Ralph E.
Mannik, Katrin
Ophoff, Roel A.
Karpyak, Victor M.
Culverhouse, Robert C.
Penninx, Brenda W. J. H.
Dong, Li
Meulenbelt, Ingrid
Kalsi, Gursharan
La Via, Maria C.
Zerwas, Stephanie
Strober, Michael
Giegling, Ina
Palviainen, Teemu
Lissowska, Jolanta
Copeland, William E.
Danner, Unna N.
Magnusson, Patrik K. E.
Meyers, Jacquelyn L.
Szatkiewicz, Jin P.
Brandt, Harry
Kim, Youl R.
Preuss, Ulrich
Boraska Perica, Vesna
Hayward, Caroline
Gelernter, Joel
Forzan, Monica
Martin, Nicholas G.
Iacono, William G.
Foo, Jerome C.
Degenhardt, Louisa
Docampo, Elisa
Zhou, Hang
Wetherill, Leah
Cichon, Sven
Clementi, Maurizio
Duncan, Laramie E.
Monteleone, Alessio Maria
Alfredsson, Lars
Schork, Nicholas J.
Hodgkinson, Colin
Foroud, Tatiana M.
Danae Lin, Bochao
Kas, Martien J.H.
Choi, Doo-Sup
Ritschel, Franziska
Ntalla, Ioanna
Kramer, John
Ising, Marcus
Fischer, Krista
Gallinger, Steven
Ridinger, Monika
Horwood, L. John
Jordan, Jennifer
Riley, Brien P.
Biernacka, Joanna M.
Hinney, Anke
Widen, Elisabeth
Wills, Amanda G.
Slof-Op't Landt, Margarita C. T.
Brown, Sandra A.
McIntosh, Andrew M.
Föcker, Manuel
Hauser, Joanna
Ehrlich, Stefan
Clarke, Toni-Kim
Hancock, Dana B.
Hopfer, Christian J.
Schosser, Jochen
Degenhardt, Franziska
Adkins, Daniel E.
Slopien, Agnieszka
Zhao, Hongyu
Burghardt, Roland
Adkins, Amy E.
Mann, Karl
Tziouvas, Konstantinos
Thomas, Nathaniel
Klump, Kelly L.
Vanyukov, Michael M.
Lucae, Susanne
Boehm, Ilka
Henders, Anjali K.
Wang, Jen-Chyong
Tozzi, Federica
Bigdeli, Tim B.
Marsal, Sara
Bo Mortensen, Preben
Crow, Scott
Mitchell, Karen
Ligthart, Lannie
Giuranna, Johanna
Janout, Vladimir
Heilmann Heimbach, Stefanie
Kiefer, Falk
Imgart, Hartmut
Edenberg, Howard J.
Soyka, Michael
Walton, Esther
Jiménez-Murcia, Susana
Davis, Oliver S. P.
Micali, Nadia
Müller Myhsok, Bertram
Hellard, Stephanie Le
Keski Rahkonen, Anna
Sullivan, Patrick F.
Dikeos, Dimitris
Hartmann, Annette M.
Lahti, Jari
Webb, Bradley T.
Hudson, James I.
Diazgranados, Nancy
Karhunen, Leila
Sorbi, Sandro
Hebebrand, Johannes
Gratacos Mayora, Monica
Andreassen, Ole A.
Dedoussis, George
Krauter, Kenneth
Estivill, Xavier, 1955-
Costello, E. Jane
Guillaume, Sébastien
Navratilova, Marie
Leppä, Virpi M.
Sanchez Roige, Sandra
Kennedy, James L.
Whitfield, John B.
Tsitsika, Artemis
Crawford, Steven
Treutlein, Jens
Keyes, Margaret
Świątkowska, Beata
Zeggini, Eleftheria
Treasure, Janet
Monteleone, Palmiero
Vrieze, Scott
McGue, Matt
Nöthen, Markus M.
Bergen, Andrew W.
Nacmias, Benedetta
Räikkönen, Katri
Herms, Stefan
Ricca, Valdo
Keywords: Trastorns de la conducta alimentària
Genètica
Factors de risc en les malalties
Fenotip
Consum d'alcohol
Abús de substàncies
Eating disorders
Genetics
Risk factors in diseases
Phenotype
Drinking of alcoholic beverages
Substance abuse
Issue Date: 16-Feb-2020
Publisher: Wiley
Abstract: Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors.
Note: Versió postprint del document publicat a: https://doi.org/10.1111/adb.12880
It is part of: Addiction Biology, 2020, vol. 26(1), num. e12880
URI: http://hdl.handle.net/2445/174530
Related resource: https://doi.org/10.1111/adb.12880
ISSN: 1355-6215
Appears in Collections:Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))
Articles publicats en revistes (Ciències Clíniques)
Articles publicats en revistes (Genètica, Microbiologia i Estadística)

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