Title: | Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies |
Author: | Munn Chernoff, Melissa A. Johnson, Emma C. Chou, Yi Ling Coleman, Jonathan R. I. Thornton, Laura M. Walters, Raymond K. Yilmaz, Zeynep Baker, Jessica H. Hübel, Christopher Gordon, Scott Medland, Sarah E. Meyers, Jacquelyn L. Nacmias, Benedeta Kuperman, Samuel Van Elburg, Annemarie A. O'Toole, Julie K. Karwautz, Andreas Heath, Andrew C. Kaye, Walter H. Slof-Op't Landt, Margarita C. T. Larsen, Janne T. Hanscombe, Ken B. Van Furth, Eric F. Ryu, Euijung Maes, Hermine H. Lahti Pulkkinen, Marius Estivill, Xavier, 1955- Saccone, Nancy L. Lissowska, Jolanta Degenhardt, Louisa Ritschel, Franziska Brown, Sandra A. Adkins, Amy E. Johnson, Craig Vanyukov, Michael M. Ligthart, Lannie Giuranna, Johanna Janout, Vladimir Heilmann Heimbach, Stefanie Kiefer, Falk Imgart, Hartmut Edenberg, Howard J. Walton, Esther Micali, Nadia Müller Myhsok, Bertram Hellard, Stephanie Le Keski Rahkonen, Anna Sullivan, Patrick F. Dikeos, Dimitris Hartmann, Annette M. Webb, Bradley T. Hudson, James I. Diazgranados, Nancy Hebebrand, Johannes Gratacos Mayora, Monica Andreassen, Ole A. Dedoussis, George Krauter, Kenneth Costello, E. Jane Guillaume, Sébastien Navratilova, Marie Leppä, Virpi M. Kennedy, James L. Tsitsika, Artemis Crawford, Steve Treutlein, Jens Świątkowska, Beata Zeggini, Eleftheria Treasure, Janet Monteleone, Palmiero Vrieze, Scott Nöthen, Markus M. Bergen, Andrew W. Räikkönen, Katri Ricca, Valdo Marshall, Christian R. Stallings, Michael C. Chen, Danfeng Hatzikotoulas, Konstantinos Gaspar, Héléna A. Zwaan, Martina de Lilenfeld, Lisa Scherer, Stephen W. Dina, Christian Scherbaum, Norbert Schosser, Alexandra Goldman, David Kaplan, Allan S. Tortorella, Alfonso DeSocio, Janiece E. Rietschel, Marcella Pearson, John F. Wit, Harriet de Esko, Tõnu Padyukov, Leonid Guo, Yiran Rice, John P. Pantel, Jacques Helder, Sietske G. Schuckit, Marc A. Crow, Scott Degortes, Daniela Dmitrzak Weglarz, Monika Rotondo, Alessandro Schmidt, Ulrike Batzler, Anthony Johnson, Eric O. Penninx, Brenda W. J. H. Rybakowski, Filip Shen, Pei-Hong Docampo, Elisa Choi, Doo-Sup Widen, Elisabeth Slopien, Agnieszka Aliev, Fazil Copeland, William E. Bigdeli, Tim B. Jiménez-Murcia, Susana Sorbi, Sandro Whitfield, John B. Edwards, Alexis C. Wall, Tamara L. Courtet, Philippe Konte, Bettina Goate, Alison M. Maj, Mario Palmer, Abraham A. Maier, Wolfgang Frye, Mark A. Franklin, Christopher S. Bulik, Cynthia M. Inoko, Hidetoshi Sherva, Richard Montgomery, Grant W. Egberts, Karim Kaprio, Jaakko Bertelsen, Sarah Bucholz, Kathleen K. Metspalu, Andres Wodarz, Norbert Kennedy, Martin A Levitan, Robert D. Ripke, Stephan Murray, Alison D. Norring, Claes Buehren, Katharina Gäbel, Wolfgang Woodside, D. Blake Neale, Benjamin M. Ando, Tetsuya Grucza, Richard A. Reichborn Kjennerud, Tez Streit, Fabian Julià, Antonio Lynskey, Michael T. Gorwood, Philip Halmi, Katherine A. Tenconi, Elena Li-Shiun , Chen Männistö, Satu Papezova, Hana McQueen, Matthew B. Nurnberger, John I Schwandt, Melanie Kaminská, Deborah Bacanu, Silviu Alin Landén, Mikael Mattingsdal, Morten Domingue, Benjamin W. Rose, Richard J. Bryois, Julien Farrer, Lindsay A. Huckins, Laura M. Kranzler, Henry R. Watson, Hunna J. Dick, Danielle M. McDevitt, Sara Hartz, Sarah M. Madden, Pamela A.F . Nelson, Elliot C. Tachmazidou, Ioanna Herzog, Wolfgang Hesselbrock, Victor Danner, Unna N. Iacono, William G. Hodgkinson, Colin Horwood, L. John Ehrlich, Stefan Tziouvas, Konstantinos Wagner, Gudrun Davis, Oliver S. P. Karhunen, Leila Sanchez Roige, Sandra McGue, Matt Salvatore, Jessica E. Parker, Richard Grove, Jakob Hoffmann, Per Docherty, Anna R. Cassina, Matteo Adan, Robert A. H. Eriksson, Johan G. Slagboom, P. Eline Loukola, Anu Birgegård, Andreas Bierut, Laura J. Rujescu, Dan Hewitt, John K. Kendler, Kenneth S. Zipfel, Stephan Agrawal, Arpana Roberts, Marion Pinto, Dalila Peterson, Roseann E. Reynolds, Maureen D. Breen, Gerome Gillespie, Nathan A. Fox, Louis Escaramís, Geòrgia Forstner, Andreas J. Porjesz, Bernice Berrettini, Wade H. Boomsma, Dorret I. Koller, Gabriele Frank, Josef Magistretti, Pierre J. Polimanti, Renato Boden, Joseph M. Zill, Peter Mitchell, James Scherag, André Mbarek, Hamdi Herpertz-Dahlmann, Beate Dahmen, Norbert Silberg, Judy Luykx, Jurjen McClintick, Jeanette N. Slachtova, Lenka Gonidakis, Fragiskos Santonastaso, Paolo Pedersen, Nancy L. Mattheisen, Manuel Hack, Laura M. Rabionet Janssen, Raquel Mullan Harris, Kathleen Tyszkiewicz Nwafor, Marta Hottenga, Jouke Jan Palotie, Aarno McGuffin, Peter Giusti Rodríguez, Paola Tarter, Ralph E. Mannik, Katrin Ophoff, Roel A. Karpyak, Victor M. Dong, Li Olsen, Catherine M. Ising, Marcus Marsal, Sara Soyka, Michael Lahti, Jari Keyes, Margaret Herms, Stefan Witt, Stephanie H. Strohmaier, Jana Kiezebrink, Kirsty Boardman, Jason D. Knudsen, Gun Peggy S. Lind, Penelope A. Dongbing, Lai Wade, Tracey D. Hakonarson, Hakon Ripatti, Samuli Ramoz, Nicolas Meulenbelt, Ingrid Kalsi, Gursharan La Via, Maria C. Zerwas, Stephanie Strober, Michael Giegling, Ina Palviainen, Teemu Magnusson, Patrik K. E. Szatkiewicz, Jin P. Brandt, Harry Kim, Youl R. Preuss, Ulrich Boraska Perica, Vesna Hayward, Caroline Gelernter, Joel Martin, Nicholas G. Foo, Jerome C. Zhou, Hang Wetherill, Leah Cichon, Sven Clementi, Maurizio Duncan, Laramie E. Alfredsson, Lars Schork, Nicholas J. Foroud, Tatiana M. Danae Lin, Bochao Kas, Martien J.H. Ntalla, Ioanna Kramer, John Fischer, Krista Gallinger, Steven Ridinger, Monika Jordan, Jennifer Riley, Brien P. Biernacka, Joanna M. Hinney, Anke Wills, Amanda G. McIntosh, Andrew M. Föcker, Manuel Hauser, Joanna Clarke, Toni-Kim Hancock, Dana B. Hopfer, Christian J. Schosser, Jochen Degenhardt, Franziska Zhao, Hongyu Burghardt, Roland Mann, Karl Thomas, Nathaniel Werge, Thomas Cone, Roger D. Milaneschi, Yuri Raevuori, Anu Lichtenstein, Paul Yao, Shuyang Maher, Brion S. Foretova, Lenka Boni, Claudette Wedow, Robbee MacKillop, James Fichter, Manfred M. Crowley, James J. Culverhouse, Robert C. Forzan, Monica Monteleone, Alessio Maria Adkins, Daniel E. Klump, Kelly L. Lucae, Susanne Boehm, Ilka Henders, Anjali K. Wang, Jen-Chyong Tozzi, Federica Bo Mortensen, Preben Mitchell, Karen |
Keywords: | Trastorns de la conducta alimentària Genètica Factors de risc en les malalties Fenotip Consum d'alcohol Abús de substàncies Eating disorders Genetics Risk factors in diseases Phenotype Drinking of alcoholic beverages Substance abuse |
Issue Date: | 16-Feb-2020 |
Publisher: | Wiley |
Abstract: | Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [rg ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phenotypes (anorexia nervosa [AN], AN with binge eating, AN without binge eating, and a bulimia nervosa factor score), and eight substance-use-related phenotypes (drinks per week, alcohol use disorder [AUD], smoking initiation, current smoking, cigarettes per day, nicotine dependence, cannabis initiation, and cannabis use disorder) from eight studies were included. Significant genetic correlations were adjusted for variants associated with major depressive disorder and schizophrenia. Total study sample sizes per phenotype ranged from ~2400 to ~537 000 individuals. We used linkage disequilibrium score regression to calculate single nucleotide polymorphism-based genetic correlations between eating disorder- and substance-use-related phenotypes. Significant positive genetic associations emerged between AUD and AN (rg = 0.18; false discovery rate q = 0.0006), cannabis initiation and AN (rg = 0.23; q < 0.0001), and cannabis initiation and AN with binge eating (rg = 0.27; q = 0.0016). Conversely, significant negative genetic correlations were observed between three nondiagnostic smoking phenotypes (smoking initiation, current smoking, and cigarettes per day) and AN without binge eating (rgs = -0.19 to -0.23; qs < 0.04). The genetic correlation between AUD and AN was no longer significant after co-varying for major depressive disorder loci. The patterns of association between eating disorder- and substance-use-related phenotypes highlights the potentially complex and substance-specific relationships among these behaviors. |
Note: | Versió postprint del document publicat a: https://doi.org/10.1111/adb.12880 |
It is part of: | Addiction Biology, 2020, vol. 26(1), num. e12880 |
URI: | http://hdl.handle.net/2445/174530 |
Related resource: | https://doi.org/10.1111/adb.12880 |
ISSN: | 1355-6215 |
Appears in Collections: | Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL)) Articles publicats en revistes (Ciències Clíniques) Articles publicats en revistes (Genètica, Microbiologia i Estadística)
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