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Title: Clinical, pathological and PAM50 gene expression features of HER2-low breast cancer
Author: Prat Aparicio, Aleix
Schettini, Francesco
Chic, Núria
Brasó Maristany, Fara
Paré Brunet, Laia
Pascual, Tomás
Conte, Benedetta
Martínez Sáez, Olga
Adamo, Barbara
Vidal Losada, Maria Jesús
Fernández Martínez, Aranzazu
González-Farre, Blanca
Sanfeliu, Esther
Cejalvo Andújar, Juan Miguel
Perrone, Giuseppe
Sabarese, Giovanna
Zalfa, Francesca
Villagrasa, Patricia
Gavilá, Joaquín
Barrios, Carlos H.
Lluch, Ana
Martín, Miguel
Placido, Sabino De
Barnadas, Esther
Locci, Mariavittoria
Peg, Vicente
Fasan, Roberta
Keywords: Càncer de mama
Expressió gènica
Breast cancer
Gene expression
Issue Date: 4-Jan-2021
Publisher: Springer Nature
Abstract: Novel antibody-drug conjugates against HER2 are showing high activity in HER2-negative breast cancer (BC) with low HER2 expression (i.e., 1+ or 2+ and lack of ERBB2 amplification). However, the clinical and molecular features of HER2-low BC are yet to be elucidated. Here, we collected retrospective clinicopathological and PAM50 data from 3,689 patients with HER2-negative disease and made the following observations. First, the proportion of HER2-low was higher in HR-positive disease (65.4%) than triple-negative BC (TNBC, 36.6%). Second, within HR-positive disease, ERBB2 and luminal-related genes were more expressed in HER2-low than HER2 0. In contrast, no gene was found differentially expressed in TNBC according to HER2 expression. Third, within HER2-low, ERBB2 levels were higher in HR-positive disease than TNBC. Fourth, HER2-low was not associated with overall survival in HR-positive disease and TNBC. Finally, the reproducibility of HER2-low among pathologists was suboptimal. This study emphasizes the large biological heterogeneity of HER2-low BC, and the need to implement reproducible and sensitive assays to measure low HER2 expression.
Note: Reproducció del document publicat a:
It is part of: Npj Breast Cancer, 2021, vol. 7
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Appears in Collections:Articles publicats en revistes (Medicina)
Articles publicats en revistes (IDIBAPS: Institut d'investigacions Biomèdiques August Pi i Sunyer)

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