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Title: The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study
Author: Salas Lorenzo, Isabel
Chisaguano Tonato, Aida Maribel
Garza Puentes, Andrea de la
Nieto, Ana
Herrmann, Florian
Dieguez, Estefanía
Castellote Bargalló, Ana Isabel
López Sabater, María del Carmen
Rodríguez-Palmero Seuma, María
Campoy Folgoso, Cristina
Keywords: Llet materna
Alimentació infantil
Àcids grassos omega-3
Breast milk
Child nutrition
Omega-3 fatty acids
Issue Date: 12-Mar-2019
Publisher: MDPI
Abstract: Polymorphisms in the fatty acid desaturase (FADS) genes influence the arachidonic (AA) and docosahexaenoic (DHA) acid concentrations (crucial in early life). Infants with specific genotypes may require different amounts of these fatty acids (FAs) to maintain an adequate status. The aim of this study was to determine the effect of an infant formula supplemented with AA and DHA on FAs of infants with different FADS genotypes. In total, 176 infants from the COGNIS study were randomly allocated to the Standard Formula (SF; n = 61) or the Experimental Formula (EF; n = 70) group, the latter supplemented with AA and DHA. Breastfed infants were added as a reference group (BF; n = 45). FAs and FADS polymorphisms were analyzed from cheek cells collected at 3 months of age. FADS minor allele carriership in formula fed infants, especially those supplemented, was associated with a declined desaturase activity and lower AA and DHA levels. Breastfed infants were not affected, possibly to the high content of AA and DHA in breast milk. The supplementation increased AA and DHA levels, but mostly in major allele carriers. In conclusion, infant FADS genotype could contribute to narrow the gap of AA and DHA concentrations between breastfed and formula fed infants.
Note: Reproducció del document publicat a:
It is part of: Nutrients, 2019, vol. 11, num. 3
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ISSN: 2072-6643
Appears in Collections:Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

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