Please use this identifier to cite or link to this item:
http://hdl.handle.net/2445/175317
Title: | Cysteine and Folate metabolism are targetable vulnerabilities of metastatic colorectal cancer |
Author: | Tarragó-Celada, Josep Foguet Coll, Carles Tarrado Castellarnau, Míriam Neus Marín Martínez, Silvia Hernández-Alias, Xavier Perarnau, Jordi Morrish, Fionnuala Hockenbery, David Gomis i Cabré, Roger Ruppin, Eytan Yuneva, Mariia Atauri Carulla, Ramón de Cascante i Serratosa, Marta |
Keywords: | Càncer colorectal Metàstasi Metabolisme Colorectal cancer Metastasis Metabolism |
Issue Date: | 23-Jan-2021 |
Publisher: | MDPI |
Abstract: | With most cancer-related deaths resulting from metastasis, the development of new therapeutic approaches against metastatic colorectal cancer (mCRC) is essential to increasing patient survival. The metabolic adaptations that support mCRC remain undefined and their elucidation is crucial to identify potential therapeutic targets. Here, we employed a strategy for the rational identification of targetable metabolic vulnerabilities. This strategy involved first a thorough metabolic characterisation of same-patient-derived cell lines from primary colon adenocarcinoma (SW480), its lymph node metastasis (SW620) and a liver metastatic derivative (SW620-LiM2), and second, using a novel multi-omics integration workflow, identification of metabolic vulnerabilities specific to the metastatic cell lines. We discovered that the metastatic cell lines are selectively vulnerable to the inhibition of cystine import and folate metabolism, two key pathways in redox homeostasis. Specifically, we identified the system xCT and MTHFD1 genes as potential therapeutic targets, both individually and combined, for combating mCRC. |
Note: | Reproducció del document publicat a: https://doi.org/10.3390/cancers13030425 |
It is part of: | Cancers, 2021, vol. 13, num. 3, p. 425 |
URI: | http://hdl.handle.net/2445/175317 |
Related resource: | https://doi.org/10.3390/cancers13030425 |
ISSN: | 2072-6694 |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Biomedicina Molecular) |
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