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http://hdl.handle.net/2445/175887
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DC Field | Value | Language |
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dc.contributor.author | Carbó, José M. | - |
dc.contributor.author | León Moreno, Theresa Elizabeth | - |
dc.contributor.author | Font-Díaz, Joan | - |
dc.contributor.author | De la Rosa, Juan Vladimir | - |
dc.contributor.author | Castrillo, Antonio | - |
dc.contributor.author | Picard, Felix R. | - |
dc.contributor.author | Staudenraus, Danel | - |
dc.contributor.author | Huber, Magdalena | - |
dc.contributor.author | Cedó Giné, Lídia | - |
dc.contributor.author | Escolà Gil, Joan Carles | - |
dc.contributor.author | Campos, Lucía | - |
dc.contributor.author | Bakiri, Latifa | - |
dc.contributor.author | Wagner, Erwin F. | - |
dc.contributor.author | Caelles Franch, Carme | - |
dc.contributor.author | Stratmann, Thomas | - |
dc.contributor.author | Van Ginderachter, J.A. | - |
dc.contributor.author | Valledor Fernández, Annabel | - |
dc.date.accessioned | 2021-03-30T15:19:23Z | - |
dc.date.available | 2021-12-23T06:10:19Z | - |
dc.date.issued | 2020-12-23 | - |
dc.identifier.issn | 0008-5472 | - |
dc.identifier.uri | http://hdl.handle.net/2445/175887 | - |
dc.description.abstract | Liver X receptors (LXR) are transcription factors from the nuclear receptor family that are activated by oxysterols and synthetic high-affinity agonists. In this study, we assessed the anti-tumor effects of synthetic LXR agonist TO901317 in a murine model of syngeneic Lewis Lung carcinoma. Treatment with TO901317 inhibited tumor growth in wild-type but not in LXR-deficient mice, indicating that the anti-tumor effects of the agonist depends on functional LXR activity in host cells. Pharmacological activation of the LXR pathway reduced the intratumoral abundance of regulatory T cells (Treg) and the expression of the Treg-attracting chemokine Ccl17 by MHCIIhigh tumor-associated macrophages (TAM). Moreover, gene expression profiling indicated a broad negative impact of the LXR agonist on other mechanisms used by TAM for the maintenance of an immunosuppressive environment. In studies exploring the macrophage response to GM-CSF or IL-4, activated LXR repressed IRF4 expression, resulting in subsequent downregulation of IRF4-dependent genes including Ccl17. Taken together, this work reveals the combined actions of the LXR pathway in the control of TAM responses that contribute to the anti-tumoral effects of pharmacological LXR activation. Moreover, these data provide new insights for the development of novel therapeutic options for the treatment of cancer. | - |
dc.format.extent | 19 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | American Association for Cancer Research | - |
dc.relation.isformatof | Versió postprint del document publicat a: https://doi.org/10.1158/0008-5472.CAN-19-3360 | - |
dc.relation.ispartof | Cancer Research, 2020, vol. 81, num. 4 | - |
dc.relation.uri | https://doi.org/10.1158/0008-5472.CAN-19-3360 | - |
dc.rights | (c) American Association for Cancer Research, 2020 | - |
dc.source | Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) | - |
dc.subject.classification | Receptors nuclears (Bioquímica) | - |
dc.subject.classification | Càncer | - |
dc.subject.other | Nuclear receptors (Biochemistry) | - |
dc.subject.other | Cancer | - |
dc.title | Pharmacological activation of LXR alters the expression profile of tumor-associated macrophages and the abundance of regulatory T cells in the tumor microenvironment | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/acceptedVersion | - |
dc.identifier.idgrec | 706308 | - |
dc.date.updated | 2021-03-30T15:19:23Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (Bioquímica i Fisiologia) Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia) |
Files in This Item:
File | Description | Size | Format | |
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706308.pdf | 4.66 MB | Adobe PDF | View/Open |
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