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Title: Meteorin-like/ Meteorin-b protects heart against cardiac dysfunction
Author: Rupérez, Celia
Ferrer Curriu, Gemma
Cervera Barea, Aina
Florit, Laura
Guitart Mampel, Mariona
Garrabou Tornos, Glòria
Zamora, Monica
Crispi Brillas, Fàtima
Fernández-Solà, J. (Joaquim)
Lupón, Josep
Bayés Genís, Antoni
Villarroya i Gombau, Francesc
Planavila Porta, Ana
Keywords: Malalties cardiovasculars
Metabolisme de proteïnes
Cardiovascular diseases
Protein metabolism
Issue Date: 3-May-2021
Publisher: Rockefeller University Press
Abstract: Meteorin-like/Meteorin-β (Metrnl/Metrnβ) is a secreted protein produced by skeletal muscle and adipose tissue that exerts metabolic actions that improve glucose metabolism. The role of Metrnβ in cardiac disease is completely unknown. Here, we show that Metrnβ-null mice exhibit asymmetrical cardiac hypertrophy, fibrosis, and enhanced signs of cardiac dysfunction in response to isoproterenol-induced cardiac hypertrophy and aging. Conversely, adeno-associated virus-mediated specific overexpression of Metrnβ in the heart prevents the development of cardiac remodeling. Furthermore, Metrnβ inhibits cardiac hypertrophy development in cardiomyocytes in vitro, indicating a direct effect on cardiac cells. Antibody-mediated blockage of Metrnβ in cardiomyocyte cell cultures indicated an autocrine action of Metrnβ on the heart, in addition to an endocrine action. Moreover, Metrnβ is highly produced in the heart, and analysis of circulating Metrnβ concentrations in a large cohort of patients reveals that it is a new biomarker of heart failure with an independent prognostic value.
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It is part of: Journal of Experimental Medicine, 2021, vol. 218, num. 5, p. e20201206
Related resource:
ISSN: 0022-1007
Appears in Collections:Articles publicats en revistes (Bioquímica i Biomedicina Molecular)
Articles publicats en revistes (Medicina)

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