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http://hdl.handle.net/2445/177945
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DC Field | Value | Language |
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dc.contributor.author | Martínez-Peinado, Nieves | - |
dc.contributor.author | Cortés Serra, Núria | - |
dc.contributor.author | Torras Claveria, Laura | - |
dc.contributor.author | Pinazo, Maria-Jesus | - |
dc.contributor.author | Gascón i Brustenga, Joaquim | - |
dc.contributor.author | Bastida Armengol, Jaume | - |
dc.contributor.author | Alonso Padilla, Julio | - |
dc.date.accessioned | 2021-06-03T08:03:17Z | - |
dc.date.available | 2021-06-03T08:03:17Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1756-3305 | - |
dc.identifier.uri | http://hdl.handle.net/2445/177945 | - |
dc.description.abstract | Background: Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected disease that afects ~7 million people worldwide. Development of new drugs to treat the infection remains a priority since those currently available have frequent side efects and limited efcacy at the chronic stage. Natural products provide a pool of diver sity structures to lead the chemical synthesis of novel molecules for this purpose. Herein we analyzed the anti-T. cruzi activity of nine alkaloids derived from plants of the family Amaryllidaceae. Methods: The activity of each alkaloid was assessed by means of an anti-T. cruzi phenotypic assay. We further evalu ated the compounds that inhibited parasite growth on two distinct cytotoxicity assays to discard those that were toxic to host cells and assure parasite selectivity. Results: We identifed a single compound (hippeastrine) that was selectively active against the parasite yielding selectivity indexes of 12.7 and 35.2 against Vero and HepG2 cells, respectively. Moreover, it showed specifc activity against the amastigote stage (IC50=3.31 μM). Conclusions: Results reported here suggest that natural products are an interesting source of new compounds for the development of drugs against Chagas disease. Keywords: Chagas disease, Trypanosoma cruzi, Alkaloids, Amaryllidaceae, Hippeastrine, Phenotypic assays, Cytotoxicity | - |
dc.format.extent | 10 p. | - |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central | - |
dc.relation.isformatof | Reproducció del document publicat a: https://doi.org/10.1186/s13071-020-04171-6 | - |
dc.relation.ispartof | Parasites & Vectors, 2020, vol. 13, num. 299, p. 1-10 | - |
dc.relation.uri | https://doi.org/10.1186/s13071-020-04171-6 | - |
dc.rights | cc-by (c) Martínez-Peinado, Nieves et al., 2020 | - |
dc.rights.uri | https://creativecommons.org/licenses/by/4.0/ | - |
dc.source | Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) | - |
dc.subject.classification | Malaltia de Chagas | - |
dc.subject.classification | Marcadors bioquímics | - |
dc.subject.classification | Alcaloides | - |
dc.subject.other | Chagas' disease | - |
dc.subject.other | Biochemical markers | - |
dc.subject.other | Alkaloids | - |
dc.title | Amaryllidaceae alkaloids with anti-Trypanosoma cruzi activity | - |
dc.type | info:eu-repo/semantics/article | - |
dc.type | info:eu-repo/semantics/publishedVersion | - |
dc.identifier.idgrec | 708605 | - |
dc.date.updated | 2021-06-03T08:03:17Z | - |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | - |
Appears in Collections: | Articles publicats en revistes (ISGlobal) Articles publicats en revistes (Biologia, Sanitat i Medi Ambient) |
Files in This Item:
File | Description | Size | Format | |
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708605.pdf | 1.67 MB | Adobe PDF | View/Open |
This item is licensed under a Creative Commons License